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- W1985148439 endingPage "435" @default.
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- W1985148439 abstract "In spite of recent advances in surgical and medical therapies, the prognosis for patients diagnosed with the high-grade glioma glioblastoma multiforme remains poor. In this Review, Das et al. present evidence that the resistance of these tumors to current therapies is attributable to a small subpopulation of cancer stem cells, and they consider potential new therapeutic strategies that specifically target this cell population. Despite continued advances in surgical and medical therapies, the outcomes for patients diagnosed with glioblastoma multiforme remain dismal. Recent data suggest that progression of these brain tumors is driven by a small subpopulation of tumor cells, which are termed cancer stem cells (CSCs) because of their capability to self-renew, proliferate and give rise to progeny of multiple neuroepithelial lineages. According to the CSC hypothesis, current therapies that are extremely cytotoxic to the bulk of highly proliferative tumor cells fail to obliterate the relatively quiescent and resistant CSC compartment, thereby allowing these cells to survive and drive tumor recurrence. This Review summarizes current knowledge regarding neural stem cells in the normal adult brain and CSCs in glial tumors and discusses the implications of the CSC hypothesis for the development of future therapies for brain tumors." @default.
- W1985148439 created "2016-06-24" @default.
- W1985148439 creator A5020396889 @default.
- W1985148439 creator A5029832154 @default.
- W1985148439 creator A5043558906 @default.
- W1985148439 date "2008-07-15" @default.
- W1985148439 modified "2023-10-04" @default.
- W1985148439 title "Cancer stem cells and glioma" @default.
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- W1985148439 doi "https://doi.org/10.1038/ncpneuro0862" @default.
- W1985148439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18628751" @default.