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- W1985149849 abstract "Abstract In the mouse retina, there are two distinct groups of direction‐selective ganglion cells, ON and ON – OFF , that detect movement of visual images. To understand the roles of these cells in controlling eye movements, we studied the optokinetic responses ( OKR s) of mutant mice with dysfunctional ON ‐bipolar cells that have a functional obstruction of transmission to ON direction‐selective ganglion cells. Experiments were carried out to examine the initial and late phases of OKR s. The initial phase was examined by measurement of eye velocity using stimuli of sinusoidal grating patterns of various spatiotemporal frequencies that moved for 0.5 s. The mutant mice showed significant initial OKR s, although the range of spatiotemporal frequencies that elicited these OKR s was limited and the response magnitude was weaker than that in wild‐type mice. To examine the late phase of the OKR s, the same visual patterns were moved for 30 s to induce alternating slow and quick eye movements (optokinetic nystagmus) and the slow‐phase eye velocity was measured. Wild‐type mice showed significant late OKR s with a stimulus in an appropriate range of spatiotemporal frequencies (0.0625–0.25 cycles/°, 0.75–3.0 Hz, 3–48°/s), but mutant mice did not show late OKR s in response to the same visual stimuli. The results suggest that two groups of direction‐selective ganglion cells play different roles in OKR s: ON direction‐selective ganglion cells contribute to both initial and late OKR s, whereas ON – OFF direction‐selective ganglion cells contribute to OKR s only transiently." @default.
- W1985149849 created "2016-06-24" @default.
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- W1985149849 date "2013-06-12" @default.
- W1985149849 modified "2023-10-04" @default.
- W1985149849 title "Contributions of retinal direction-selective ganglion cells to optokinetic responses in mice" @default.
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- W1985149849 doi "https://doi.org/10.1111/ejn.12284" @default.
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