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• W1985152227 endingPage "94" @default.
• W1985152227 startingPage "83" @default.
• W1985152227 abstract "Neuronal migration is a fundamental biological process that enables the precise positioning of neurons to form functional circuits. Cortical neurons migrate along glial scaffolds formed by radial glia guided by Reelin ligand. However, it is unclear whether the Reelin-directed behavior of radial glia is also critical for positioning the spinal neurons. Here we demonstrate a novel role of radial glia that confines motor neurons within the neural tube and is promoted by Reelin and Notch signaling. Spinal radial glia express the Dab1 adaptor for Reelin signaling and are surrounded by Reelin. In reeler mice, in which Reelin is absent, ectopic motor neurons are found outside the neural tube, although they appear to maintain their identity. Boundary cap (BC) cells, Schwann cell precursors and the basal lamina at motor exit points are intact, whereas the glia limitans of radial glia are disorganized and detached from the basement membrane. The sparse and irregular radial scaffold is wide enough to allow motor somata to pass. Forced activation of Notch signaling rescued the structural defects in radial glia in reeler mice and the appearance of extraspinal neurons. In the absence of Reelin, Notch intracellular domain (NICD) protein level was reduced. In addition, disrupting the radial glia scaffold by destroying its polarity induced ectopic motor neurons in chick embryos. These findings suggest that activation of the Notch pathways by Reelin is required to establish the radial glial scaffold, a structure that actively constrains motor neuron somata and specifies the CNS–PNS boundary." @default.
• W1985152227 created "2016-06-24" @default.
• W1985152227 creator A5013222112 @default.
• W1985152227 creator A5018608679 @default.
• W1985152227 date "2013-11-01" @default.
• W1985152227 modified "2023-10-16" @default.
• W1985152227 title "The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways" @default.
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• W1985152227 doi "https://doi.org/10.1016/j.expneurol.2013.08.010" @default.
• W1985152227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23988635" @default.
• W1985152227 hasPublicationYear "2013" @default.
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