FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985160889> ?p ?o ?g. }

• W1985160889 endingPage "422" @default.
• W1985160889 startingPage "417" @default.
• W1985160889 abstract "1. Adrenal and gonadal steroids are derived from cholesterol, which may be derived from plasma lipoproteins or de novo synthesis. 2. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate limiting enzyme in cholesterol synthesis, may therefore affect steroidogenesis when used as lipid-lowering agents in hypercholesterolaemia. 3. We have assessed gonadal and adrenal function in subjects with heterozygous familial hypercholesterolaemia (FH) before and after 12 weeks treatment with pravastatin, an HMG CoA reductase inhibitor, or cholestyramine as a control in maximal recommended doses. 4. No changes in measured plasma cortisol responses to tetracosactrin injection were seen in 11 patients on cholestyramine or 12 on pravastatin. 5. No changes were seen in testosterone, sex hormone binding globulin, androstenedione, dehydroepiandrosterone sulphate, oestradiol or 17 alpha-hydroxyprogesterone. 6. Gonadotrophin levels were unaffected in 10 male subjects on cholestyramine and 7 on pravastatin. 7. Measurements on a subset of subjects continuing to 24 weeks treatment also showed no changes. 8. No adverse effect on adrenal or gonadal function could be demonstrated in patients with familial hypercholesterolaemia on maximal recommended doses of pravastatin." @default.
• W1985160889 created "2016-06-24" @default.
• W1985160889 creator A5025348013 @default.
• W1985160889 creator A5031113070 @default.
• W1985160889 creator A5033223460 @default.
• W1985160889 creator A5047049633 @default.
• W1985160889 creator A5060175453 @default.
• W1985160889 creator A5061967509 @default.
• W1985160889 creator A5081329168 @default.
• W1985160889 date "1991-10-01" @default.
• W1985160889 modified "2023-10-17" @default.
• W1985160889 title "Effects of pravastatin and cholestyramine on gonadal and adrenal steroid production in familial hypercholesterolaemia." @default.
• W1985160889 cites W141327007 @default.
• W1985160889 cites W1817183609 @default.
• W1985160889 cites W1844308307 @default.
• W1985160889 cites W1963829759 @default.
• W1985160889 cites W1979320849 @default.
• W1985160889 cites W2006140375 @default.
• W1985160889 cites W2011664867 @default.
• W1985160889 cites W2016678257 @default.
• W1985160889 cites W2017602185 @default.
• W1985160889 cites W2032022098 @default.
• W1985160889 cites W2036024941 @default.
• W1985160889 cites W2043022335 @default.
• W1985160889 cites W2043775185 @default.
• W1985160889 cites W2050245455 @default.
• W1985160889 cites W2058002657 @default.
• W1985160889 cites W2064945315 @default.
• W1985160889 cites W2091571602 @default.
• W1985160889 cites W2104918389 @default.
• W1985160889 cites W2106814701 @default.
• W1985160889 cites W2116404316 @default.
• W1985160889 cites W2133315146 @default.
• W1985160889 cites W2145512527 @default.
• W1985160889 cites W2163521694 @default.
• W1985160889 cites W2165140407 @default.
• W1985160889 cites W2169935588 @default.
• W1985160889 cites W2210160338 @default.
• W1985160889 cites W2317657624 @default.
• W1985160889 cites W43331920 @default.
• W1985160889 cites W1998276235 @default.
• W1985160889 doi "https://doi.org/10.1111/j.1365-2125.1991.tb03924.x" @default.
• W1985160889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1368599" @default.
• W1985160889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1958433" @default.
• W1985160889 hasPublicationYear "1991" @default.
• W1985160889 type Work @default.
• W1985160889 sameAs 1985160889 @default.
• W1985160889 citedByCount "48" @default.
• W1985160889 countsByYear W19851608892012 @default.
• W1985160889 countsByYear W19851608892013 @default.
• W1985160889 countsByYear W19851608892014 @default.
• W1985160889 countsByYear W19851608892015 @default.
• W1985160889 countsByYear W19851608892017 @default.
• W1985160889 countsByYear W19851608892020 @default.
• W1985160889 countsByYear W19851608892022 @default.
• W1985160889 countsByYear W19851608892023 @default.
• W1985160889 crossrefType "journal-article" @default.
• W1985160889 hasAuthorship W1985160889A5025348013 @default.
• W1985160889 hasAuthorship W1985160889A5031113070 @default.
• W1985160889 hasAuthorship W1985160889A5033223460 @default.
• W1985160889 hasAuthorship W1985160889A5047049633 @default.
• W1985160889 hasAuthorship W1985160889A5060175453 @default.
• W1985160889 hasAuthorship W1985160889A5061967509 @default.
• W1985160889 hasAuthorship W1985160889A5081329168 @default.
• W1985160889 hasBestOaLocation W19851608892 @default.
• W1985160889 hasConcept C104950815 @default.
• W1985160889 hasConcept C126322002 @default.
• W1985160889 hasConcept C134018914 @default.
• W1985160889 hasConcept C134651460 @default.
• W1985160889 hasConcept C181199279 @default.
• W1985160889 hasConcept C185592680 @default.
• W1985160889 hasConcept C2777320049 @default.
• W1985160889 hasConcept C2777911890 @default.
• W1985160889 hasConcept C2778163477 @default.
• W1985160889 hasConcept C2778697171 @default.
• W1985160889 hasConcept C2779279991 @default.
• W1985160889 hasConcept C2779519902 @default.
• W1985160889 hasConcept C30092816 @default.
• W1985160889 hasConcept C55493867 @default.
• W1985160889 hasConcept C71315377 @default.
• W1985160889 hasConcept C71924100 @default.
• W1985160889 hasConceptScore W1985160889C104950815 @default.
• W1985160889 hasConceptScore W1985160889C126322002 @default.
• W1985160889 hasConceptScore W1985160889C134018914 @default.
• W1985160889 hasConceptScore W1985160889C134651460 @default.
• W1985160889 hasConceptScore W1985160889C181199279 @default.
• W1985160889 hasConceptScore W1985160889C185592680 @default.
• W1985160889 hasConceptScore W1985160889C2777320049 @default.
• W1985160889 hasConceptScore W1985160889C2777911890 @default.
• W1985160889 hasConceptScore W1985160889C2778163477 @default.
• W1985160889 hasConceptScore W1985160889C2778697171 @default.
• W1985160889 hasConceptScore W1985160889C2779279991 @default.
• W1985160889 hasConceptScore W1985160889C2779519902 @default.
• W1985160889 hasConceptScore W1985160889C30092816 @default.
• W1985160889 hasConceptScore W1985160889C55493867 @default.
• W1985160889 hasConceptScore W1985160889C71315377 @default.
• W1985160889 hasConceptScore W1985160889C71924100 @default.
• W1985160889 hasIssue "4" @default.

• next