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• W1985162216 abstract "A multidrug‐resistant (MDR) subline of the immunoblastic B lymphoma cell line was established by sequentially selecting in increasing concentrations of adriamycin. The adriamycin‐resistant cell line (HOB1/ADR) demonstrated resistance to a wide spectrum of chemotherapeutic agents including MDR drugs (Vinca alkaloids and anthracycline), antimicrotubule drug (colchicine), and DNA‐damaging agents (cisplatin and mitomycin C). The expression of human mdr 1 gene, as analyzed by RT‐PCR and Western blotting, revealed a 13–15‐fold increase in resistant cells. Unexpectedly, HOB1/ADR cells demonstrated a lack of reduced accumulation and of enhanced efflux of adriamycin. More than 60% adriamycin was effluxed at the same rate in both cell lines within 10 min. In contrast, the initial rate of vincristine accumulation was reduced by 3 fold in this resistant cell line. The maxima level of vincristine accumulation was 50% lower in the resistant cells than the parental cells. The maximal efflux rate was enhanced by 5 fold in the resistant cells. Inhibition of vincristine resistance by verapamil associated with restoration of drug accumulation, suggesting that acquired resistance in these cells is due to P‐glycoprotein. These studies demonstrated that immunoblastic B lymphoma cells selected for adriamycin resistance preferentially developed P‐glycoprotein‐mediated vincristine efflux which plays an important role in vincristine resistance. In contrast, the resistant cells did not elevate adriamycin efflux, suggesting an additional mechanism responsible for adriamycin resistance." @default.
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• W1985162216 date "1995-10-16" @default.
• W1985162216 modified "2023-09-26" @default.
• W1985162216 title "Lack of elevated drug efflux in adriamycin-resistant immunoblastic B lymphoma cells with<i>mdr</i>1 overexpression" @default.
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• W1985162216 doi "https://doi.org/10.1016/0014-5793(95)01063-k" @default.
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