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• W1985163984 abstract "The seasonal variations of estrogenic compounds and the estrogenicities of influent and effluent were investigated by chemical analysis and in vitro assay in a municipal sewage treatment plant in Wuhan (China). The levels of eight estrogenic compounds, including 17β-estradiol (E2), estrone (E1), estriol (E3), diethylstilbestrol (DES), 17α-ethinylestradiol, nonylphenol (NP), 4-tert-octylphenol (OP), and bisphenol A (BPA), were measured by gas chromatography–mass spectrometry. Total estrogenic activity of sewage was quantitatively assessed using primary cultured hepatocytes of male Megalobrama amblycephala Yih using vitellogenin as a biomarker. The E2 equivalents (EEQs) obtained from the chemical analysis were consistent with those measured by bioassay. The natural (E1, E2, and E3) and synthetic (DES) estrogens, as well as NP, were the main contributors of the total EEQs of influent and effluent in the present study. The levels of natural estrogens E1 and E3 in the influent and effluent were higher in winter than in summer, whereas the situation for NP and OP was the reverse. The levels of E2, DES, and BPA varied little among different seasons. 17α-Ethinylestradiol was not detected in the influent and effluent. The estrogenicities of the influent and of the primary and secondary effluents were all higher in summer than in winter. Estrogenic activities in winter mainly originated from natural (E1, E2, and E3) and synthetic (DES) estrogens, whereas the increase of EEQs in summer was contributed by NP. The results from chemical analysis and bioassay demonstrate that estrogenic compounds cannot be entirely removed by the existing sewage treatment process, which should be further improved to protect aquatic ecosystems and human health." @default.
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• W1985163984 date "2008-01-01" @default.
• W1985163984 modified "2023-10-16" @default.
• W1985163984 title "SEASONAL VARIATIONS OF ESTROGENIC COMPOUNDS AND THEIR ESTROGENICITIES IN INFLUENT AND EFFLUENT FROM A MUNICIPAL SEWAGE TREATMENT PLANT IN CHINA" @default.
• W1985163984 doi "https://doi.org/10.1897/07-072.1" @default.
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