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• W1985172851 abstract "Because many diseases induce early changes in tissue hemodynamic status, quantitative tissue perfusion imaging could have the capacity to characterize pathologic states, establish a diagnosis, and map the response to treatment. Since the first attempt from Kety ( 1 Kety S Measurement of regional circulation by the local clearance of radioactive sodium. Am Heart J. 1949; 38: 321 Crossref PubMed Scopus (271) Google Scholar ) to measure perfusion, calculations of perfusion have been made using different measurement techniques and different models, all based on the conservation of mass ( 2 Axel L Cerebral blood flow determination by rapid-sequence computed tomography. Radiology. 1980; 137: 679-686 Crossref PubMed Scopus (548) Google Scholar , 3 Berninger W Axel L Norman D Napel S Redington R Functional imaging of the brain using computed tomography. Radiology. 1981; 138: 711-716 Crossref PubMed Scopus (71) Google Scholar , 4 Rosen BR Belliveau JW Vevea JM Brady TJ Perfusion imaging with NMR contrast agents. Magn Res Med. 1989; 14: 249-265 Crossref Scopus (987) Google Scholar ). With its subsecond scan time and high resolution rate, slip-ring computed tomography (CT) appears well suited for tissue perfusion measurements, and fast CT has already been used to measure perfusion ( 5 Blomley M Coulden R Bufkin C Contrast bolus dynamic computed tomography for the measurement of solid organ perfusion. Invest Radiol. 1993; 28: 72-77 Crossref PubMed Scopus (113) Google Scholar ) in the cerebral ( 6 Hamberg L Hunter G Halpern E Hoop B Gazelle GS Wolf G Quantitative high-resolution measurement of cerebrovascular physiology with slip-ring CT. AJNR Am J Neuroradiol. 1996; 17: 639-650 PubMed Google Scholar ), myocardial ( 7 Rumberger J Bell M Measurement of myocardial perfusion and cardiac output using intravenous injection methods by ultrafast (cine) computed tomography. Invest Radiol. 1992; 27: 40-46 Crossref PubMed Scopus (43) Google Scholar , 8 Gould R Perfusion quantitation by ultrafast computed tomography. Invest Radiol. 1992; 27: 18-21 Crossref PubMed Scopus (21) Google Scholar ), renal ( 9 Jaschke W Gould R Cogan M Sievers R Lipton M Cine-CT measurement of cortical renal blood flow. J Comput Assist Tomogr. 1987; 11: 779-784 Crossref PubMed Scopus (39) Google Scholar ), and hepatic ( 10 Blomley M Coulden R Dawson P Liver perfusion studied with ultrafast CT. J Comput Assist Tomogr. 1995; 19: 424-433 Crossref PubMed Scopus (185) Google Scholar , 11 Miles KA Hayball MP Dixon AK Functional images of hepatic perfusion obtained with dynamic CT. Radiology. 1993; 188: 405-411 Crossref PubMed Scopus (324) Google Scholar , 12 Platt JF Francis IR Ellis JH Reige KA Liver metastases: early detection based on abnormal contrast material enhancement at dual-phased helical CT. Radiology. 1997; 205: 49-53 Crossref PubMed Scopus (72) Google Scholar , 13 Leggett DA Kelley BB Bunce IH Miles KA Colorectal cancer: diagnostic potential of CT measurements of hepatic perfusion and implications for contrast enhancement protocols. Radiology. 1997; 205: 716-720 Crossref PubMed Scopus (109) Google Scholar , 14 Halavaara J Hamberg LM Leong FS Hunter GJ Gazelle GS Wolf GL Functional CT with experimental intravascular contrast agent in the assessment of liver vascular physiology. Acad Radiol. 1996; 3: 946-952 Abstract Full Text PDF PubMed Scopus (14) Google Scholar ) circulations. By scanning sequentially at a fixed level, the passage of bolus of contrast medium may be tracked by changes in CT number within the tissue and afferent vessels. Time-attenuation curves extracted from vessel and parenchymal regions of interest (ROIs) are then used for perfusion measurement. The algorithms used are generally based on transit time measurement (the central volume theorem) or on compartmental analysis. Both types of modeling, however, are limited by the fact that the venous output is usually not measurable ( 15 Weisskoff R Chesler D Boxerman J Rosen B Pitfalls in MR measurement of tissue blood flow with intravascular tracers: which mean transit time?. Magn Reson Med. 1993; 29: 553-559 Crossref PubMed Scopus (302) Google Scholar ). Many attempts have been made to measure the hepatic blood flow (HBF). The liver's dual circulation is a considerable obstacle to its successful investigation; indeed, the liver enhancement after an injection of contrast medium results from an initial arterial input and a subsequent portal venous input." @default.
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• W1985172851 date "2002-01-01" @default.
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• W1985172851 title "Deconvolution Technique for Measuring Tissue Perfusion by Dynamic CT" @default.
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