Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985173600> ?p ?o ?g. }
- W1985173600 endingPage "1869" @default.
- W1985173600 startingPage "1866" @default.
- W1985173600 abstract "Conformational changes, including local protein folding, play important roles in protein-DNA interactions. Here, studies of the transcription factor Ets-1 provided evidence that local protein unfolding also can accompany DNA binding. Circular dichroism and partial proteolysis showed that the secondary structure of the Ets-1 DNA-binding domain is unchanged in the presence of DNA. In contrast, DNA allosterically induced the unfolding of an α helix that lies within a flanking region involved in the negative regulation of DNA binding. These findings suggest a structural basis for the intramolecular inhibition of DNA binding and a mechanism for the cooperative partnerships that are common features of many eukaryotic transcription factors." @default.
- W1985173600 created "2016-06-24" @default.
- W1985173600 creator A5000269746 @default.
- W1985173600 creator A5013666490 @default.
- W1985173600 creator A5050790320 @default.
- W1985173600 creator A5055591879 @default.
- W1985173600 creator A5070022547 @default.
- W1985173600 creator A5074685484 @default.
- W1985173600 date "1995-09-29" @default.
- W1985173600 modified "2023-09-29" @default.
- W1985173600 title "Modulation of Transcription Factor Ets-1 DNA Binding: DNA-Induced Unfolding of an α Helix" @default.
- W1985173600 cites W1498714987 @default.
- W1985173600 cites W1503263917 @default.
- W1985173600 cites W1523250495 @default.
- W1985173600 cites W172347017 @default.
- W1985173600 cites W1965010154 @default.
- W1985173600 cites W1965127482 @default.
- W1985173600 cites W1967662297 @default.
- W1985173600 cites W1969468354 @default.
- W1985173600 cites W1975085160 @default.
- W1985173600 cites W1981114387 @default.
- W1985173600 cites W1985459186 @default.
- W1985173600 cites W1996970647 @default.
- W1985173600 cites W1998903985 @default.
- W1985173600 cites W1998973642 @default.
- W1985173600 cites W2003236156 @default.
- W1985173600 cites W2005986251 @default.
- W1985173600 cites W2012318656 @default.
- W1985173600 cites W2020610229 @default.
- W1985173600 cites W2039478144 @default.
- W1985173600 cites W2040328923 @default.
- W1985173600 cites W2051628416 @default.
- W1985173600 cites W2055774900 @default.
- W1985173600 cites W205967952 @default.
- W1985173600 cites W2061632297 @default.
- W1985173600 cites W2062579188 @default.
- W1985173600 cites W2064017844 @default.
- W1985173600 cites W2064657203 @default.
- W1985173600 cites W2070550775 @default.
- W1985173600 cites W2070794112 @default.
- W1985173600 cites W207397168 @default.
- W1985173600 cites W2085719587 @default.
- W1985173600 cites W2087640316 @default.
- W1985173600 cites W2091548699 @default.
- W1985173600 cites W2095422292 @default.
- W1985173600 cites W2102026362 @default.
- W1985173600 cites W2108415605 @default.
- W1985173600 cites W2125330937 @default.
- W1985173600 cites W2146886804 @default.
- W1985173600 cites W291677162 @default.
- W1985173600 doi "https://doi.org/10.1126/science.7569926" @default.
- W1985173600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7569926" @default.
- W1985173600 hasPublicationYear "1995" @default.
- W1985173600 type Work @default.
- W1985173600 sameAs 1985173600 @default.
- W1985173600 citedByCount "175" @default.
- W1985173600 countsByYear W19851736002012 @default.
- W1985173600 countsByYear W19851736002013 @default.
- W1985173600 countsByYear W19851736002014 @default.
- W1985173600 countsByYear W19851736002015 @default.
- W1985173600 countsByYear W19851736002016 @default.
- W1985173600 countsByYear W19851736002017 @default.
- W1985173600 countsByYear W19851736002018 @default.
- W1985173600 countsByYear W19851736002019 @default.
- W1985173600 countsByYear W19851736002021 @default.
- W1985173600 crossrefType "journal-article" @default.
- W1985173600 hasAuthorship W1985173600A5000269746 @default.
- W1985173600 hasAuthorship W1985173600A5013666490 @default.
- W1985173600 hasAuthorship W1985173600A5050790320 @default.
- W1985173600 hasAuthorship W1985173600A5055591879 @default.
- W1985173600 hasAuthorship W1985173600A5070022547 @default.
- W1985173600 hasAuthorship W1985173600A5074685484 @default.
- W1985173600 hasConcept C101762097 @default.
- W1985173600 hasConcept C104317684 @default.
- W1985173600 hasConcept C12554922 @default.
- W1985173600 hasConcept C138885662 @default.
- W1985173600 hasConcept C150194340 @default.
- W1985173600 hasConcept C156719811 @default.
- W1985173600 hasConcept C179926584 @default.
- W1985173600 hasConcept C185592680 @default.
- W1985173600 hasConcept C31254050 @default.
- W1985173600 hasConcept C32010083 @default.
- W1985173600 hasConcept C33987129 @default.
- W1985173600 hasConcept C3662595 @default.
- W1985173600 hasConcept C41895202 @default.
- W1985173600 hasConcept C5179208 @default.
- W1985173600 hasConcept C54355233 @default.
- W1985173600 hasConcept C552990157 @default.
- W1985173600 hasConcept C67705224 @default.
- W1985173600 hasConcept C86339819 @default.
- W1985173600 hasConcept C86803240 @default.
- W1985173600 hasConcept C94966510 @default.
- W1985173600 hasConcept C95444343 @default.
- W1985173600 hasConceptScore W1985173600C101762097 @default.
- W1985173600 hasConceptScore W1985173600C104317684 @default.
- W1985173600 hasConceptScore W1985173600C12554922 @default.
- W1985173600 hasConceptScore W1985173600C138885662 @default.
- W1985173600 hasConceptScore W1985173600C150194340 @default.