FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985189871> ?p ?o ?g. }

• W1985189871 endingPage "11" @default.
• W1985189871 startingPage "1" @default.
• W1985189871 abstract "Cushing’s disease (CD) is a condition of chronic hypercortisolism caused by an adrenocorticotropic hormone-secreting pituitary adenoma. First-line transsphenoidal surgery is not always curative and disease sometimes recurs. Radiotherapy often requires months or years to be effective, and is also not curative in many cases. Consequently, effective medical therapies for patients with CD are needed. Corticotroph adenomas frequently express both dopamine (D2) and somatostatin receptors (predominantly sstr5). Pasireotide, a somatostatin analog with high sstr5 binding affinity, has shown urinary free cortisol (UFC) reductions in most patients with CD in a large phase 3 trial, with UFC normalization and tumor shrinkage in a subset of patients. Adverse events were similar to other somatostatin analogs, with the exception of the degree and severity of hyperglycemia. Two small trials (one prospective and one retrospective) have suggested that cabergoline, a D2 receptor agonist, could be effective in normalizing UFC, but current long-term data results are conflicting. Combination treatment with pasireotide plus cabergoline and the adrenal steroidogenesis inhibitor ketoconazole has been successful, but further investigation in larger trials is necessary. Retinoic acid also showed interesting results in a recent very small prospective study. Glucocorticoid receptor blockade with mifepristone has recently demonstrated improvement in signs and symptoms of Cushing’s and glycemic control; however, this modality does not address the etiology of the disease and has inherent adverse events related to its mechanism of action. Pituitary-targeted medical therapies will soon play a more prominent role in treating CD, and may potentially become first-line medical therapy when surgery fails or is contraindicated." @default.
• W1985189871 created "2016-06-24" @default.
• W1985189871 creator A5045002153 @default.
• W1985189871 creator A5067841207 @default.
• W1985189871 date "2013-05-15" @default.
• W1985189871 modified "2023-10-11" @default.
• W1985189871 title "New avenues in the medical treatment of Cushing’s disease: corticotroph tumor targeted therapy" @default.
• W1985189871 cites W1529179362 @default.
• W1985189871 cites W1531191121 @default.
• W1985189871 cites W1964329565 @default.
• W1985189871 cites W1965579078 @default.
• W1985189871 cites W1984025513 @default.
• W1985189871 cites W1987947990 @default.
• W1985189871 cites W1990997057 @default.
• W1985189871 cites W1993797336 @default.
• W1985189871 cites W1999655623 @default.
• W1985189871 cites W2008608773 @default.
• W1985189871 cites W2011055073 @default.
• W1985189871 cites W2016854939 @default.
• W1985189871 cites W2019911161 @default.
• W1985189871 cites W2021263508 @default.
• W1985189871 cites W2021271765 @default.
• W1985189871 cites W2026489860 @default.
• W1985189871 cites W2027091725 @default.
• W1985189871 cites W2029305086 @default.
• W1985189871 cites W2030950835 @default.
• W1985189871 cites W2032850120 @default.
• W1985189871 cites W2033505874 @default.
• W1985189871 cites W2039064285 @default.
• W1985189871 cites W2040127137 @default.
• W1985189871 cites W2055254907 @default.
• W1985189871 cites W2057835402 @default.
• W1985189871 cites W2062122986 @default.
• W1985189871 cites W2064403159 @default.
• W1985189871 cites W2064762625 @default.
• W1985189871 cites W2065729262 @default.
• W1985189871 cites W2067124381 @default.
• W1985189871 cites W2069295740 @default.
• W1985189871 cites W2070227191 @default.
• W1985189871 cites W2075882488 @default.
• W1985189871 cites W2078671813 @default.
• W1985189871 cites W2080232093 @default.
• W1985189871 cites W2082275755 @default.
• W1985189871 cites W2092459869 @default.
• W1985189871 cites W2093010614 @default.
• W1985189871 cites W2099447985 @default.
• W1985189871 cites W2102976731 @default.
• W1985189871 cites W2112260532 @default.
• W1985189871 cites W2112309011 @default.
• W1985189871 cites W2114595424 @default.
• W1985189871 cites W2114716451 @default.
• W1985189871 cites W2114808417 @default.
• W1985189871 cites W2117176864 @default.
• W1985189871 cites W2117410545 @default.
• W1985189871 cites W2117731187 @default.
• W1985189871 cites W2118708995 @default.
• W1985189871 cites W2123331233 @default.
• W1985189871 cites W2123601063 @default.
• W1985189871 cites W2129133209 @default.
• W1985189871 cites W2129462305 @default.
• W1985189871 cites W2130956345 @default.
• W1985189871 cites W2131227106 @default.
• W1985189871 cites W2132649519 @default.
• W1985189871 cites W2133418708 @default.
• W1985189871 cites W2137987440 @default.
• W1985189871 cites W2138315222 @default.
• W1985189871 cites W2142027651 @default.
• W1985189871 cites W2147573461 @default.
• W1985189871 cites W2152914748 @default.
• W1985189871 cites W2158744790 @default.
• W1985189871 cites W2159712672 @default.
• W1985189871 cites W2160063358 @default.
• W1985189871 cites W2161839947 @default.
• W1985189871 cites W2162762231 @default.
• W1985189871 cites W2167895760 @default.
• W1985189871 cites W2167999612 @default.
• W1985189871 cites W2168906621 @default.
• W1985189871 cites W2170825600 @default.
• W1985189871 cites W2171121967 @default.
• W1985189871 cites W2314616590 @default.
• W1985189871 cites W4211186562 @default.
• W1985189871 cites W4238411823 @default.
• W1985189871 cites W4246376064 @default.
• W1985189871 cites W4250141970 @default.
• W1985189871 cites W4255829341 @default.
• W1985189871 cites W4256417587 @default.
• W1985189871 doi "https://doi.org/10.1007/s11060-013-1151-1" @default.
• W1985189871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3724972" @default.
• W1985189871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23673515" @default.
• W1985189871 hasPublicationYear "2013" @default.
• W1985189871 type Work @default.
• W1985189871 sameAs 1985189871 @default.
• W1985189871 citedByCount "26" @default.
• W1985189871 countsByYear W19851898712013 @default.
• W1985189871 countsByYear W19851898712014 @default.
• W1985189871 countsByYear W19851898712015 @default.
• W1985189871 countsByYear W19851898712016 @default.
• W1985189871 countsByYear W19851898712018 @default.

• next