FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985191844> ?p ?o ?g. }

• W1985191844 endingPage "30710" @default.
• W1985191844 startingPage "30701" @default.
• W1985191844 abstract "FAS-associated factor 1 (FAF1) antagonizes Wnt signaling by stimulating β-catenin degradation. However, the molecular mechanism underlying this effect is unknown. Here, we demonstrate that the E3 ubiquitin ligase β-transducin repeat-containing protein (β-TrCP) is required for FAF1 to suppress Wnt signaling and that FAF1 specifically associates with the SCF (Skp1-Cul1-F-box protein)-β-TrCP complex. Depletion of β-TrCP reduced FAF1-mediated β-catenin polyubiquitination and impaired FAF1 in antagonizing Wnt/β-catenin signaling. FAF1 was shown to act as a scaffold for β-catenin and β-TrCP and thereby to potentiate β-TrCP-mediated β-catenin ubiquitination and degradation. Data mining revealed that FAF1 expression is statistically down-regulated in human breast carcinoma compared with normal breast tissue. Consistent with this, FAF1 expression is higher in epithelial-like MCF7 than mesenchymal-like MDA-MB-231 human breast cancer cells. Depletion of FAF1 in MCF7 cells resulted in increased β-catenin accumulation and signaling. Importantly, FAF1 knockdown promoted a decrease in epithelial E-cadherin and an increase in mesenchymal vimentin expression, indicative for an epithelial to mesenchymal transition. Moreover, ectopic FAF1 expression reduces breast cancer cell migration in vitro and invasion/metastasis in vivo. Thus, our studies strengthen a tumor-suppressive function for FAF1." @default.
• W1985191844 created "2016-06-24" @default.
• W1985191844 creator A5015796005 @default.
• W1985191844 creator A5028710085 @default.
• W1985191844 creator A5045703368 @default.
• W1985191844 creator A5046914597 @default.
• W1985191844 creator A5060352803 @default.
• W1985191844 creator A5067115806 @default.
• W1985191844 creator A5086064703 @default.
• W1985191844 date "2012-08-01" @default.
• W1985191844 modified "2023-10-11" @default.
• W1985191844 title "Fas-associated Factor 1 Is a Scaffold Protein That Promotes β-Transducin Repeat-containing Protein (β-TrCP)-mediated β-Catenin Ubiquitination and Degradation" @default.
• W1985191844 cites W1950289180 @default.
• W1985191844 cites W1958512987 @default.
• W1985191844 cites W1964677366 @default.
• W1985191844 cites W1967803088 @default.
• W1985191844 cites W1970211293 @default.
• W1985191844 cites W1989077543 @default.
• W1985191844 cites W1989215255 @default.
• W1985191844 cites W1990637280 @default.
• W1985191844 cites W1995767597 @default.
• W1985191844 cites W1997671124 @default.
• W1985191844 cites W2001943317 @default.
• W1985191844 cites W2005938222 @default.
• W1985191844 cites W2008221746 @default.
• W1985191844 cites W2018175152 @default.
• W1985191844 cites W2021820791 @default.
• W1985191844 cites W2023099007 @default.
• W1985191844 cites W2025744983 @default.
• W1985191844 cites W2026887261 @default.
• W1985191844 cites W2028642586 @default.
• W1985191844 cites W2034662853 @default.
• W1985191844 cites W2040263952 @default.
• W1985191844 cites W2040739629 @default.
• W1985191844 cites W2040942754 @default.
• W1985191844 cites W2041400512 @default.
• W1985191844 cites W2044202608 @default.
• W1985191844 cites W2045066549 @default.
• W1985191844 cites W2050189530 @default.
• W1985191844 cites W2052987988 @default.
• W1985191844 cites W2056833504 @default.
• W1985191844 cites W2062902539 @default.
• W1985191844 cites W2065431388 @default.
• W1985191844 cites W2068703154 @default.
• W1985191844 cites W2073052991 @default.
• W1985191844 cites W2077269764 @default.
• W1985191844 cites W2079478155 @default.
• W1985191844 cites W2082655555 @default.
• W1985191844 cites W2086415442 @default.
• W1985191844 cites W2109998878 @default.
• W1985191844 cites W2119284420 @default.
• W1985191844 cites W2121429119 @default.
• W1985191844 cites W2130839143 @default.
• W1985191844 cites W2132224145 @default.
• W1985191844 cites W2134408326 @default.
• W1985191844 cites W2141175150 @default.
• W1985191844 cites W2141212960 @default.
• W1985191844 cites W2146167376 @default.
• W1985191844 cites W2148294117 @default.
• W1985191844 cites W2149504763 @default.
• W1985191844 cites W2154453972 @default.
• W1985191844 cites W2155507705 @default.
• W1985191844 cites W2155753122 @default.
• W1985191844 cites W2158021558 @default.
• W1985191844 cites W2161025693 @default.
• W1985191844 cites W2163198043 @default.
• W1985191844 cites W2164618834 @default.
• W1985191844 cites W2169107231 @default.
• W1985191844 doi "https://doi.org/10.1074/jbc.m112.353524" @default.
• W1985191844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3436314" @default.
• W1985191844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22730322" @default.
• W1985191844 hasPublicationYear "2012" @default.
• W1985191844 type Work @default.
• W1985191844 sameAs 1985191844 @default.
• W1985191844 citedByCount "29" @default.
• W1985191844 countsByYear W19851918442013 @default.
• W1985191844 countsByYear W19851918442014 @default.
• W1985191844 countsByYear W19851918442015 @default.
• W1985191844 countsByYear W19851918442016 @default.
• W1985191844 countsByYear W19851918442017 @default.
• W1985191844 countsByYear W19851918442018 @default.
• W1985191844 countsByYear W19851918442019 @default.
• W1985191844 countsByYear W19851918442020 @default.
• W1985191844 countsByYear W19851918442021 @default.
• W1985191844 countsByYear W19851918442022 @default.
• W1985191844 countsByYear W19851918442023 @default.
• W1985191844 crossrefType "journal-article" @default.
• W1985191844 hasAuthorship W1985191844A5015796005 @default.
• W1985191844 hasAuthorship W1985191844A5028710085 @default.
• W1985191844 hasAuthorship W1985191844A5045703368 @default.
• W1985191844 hasAuthorship W1985191844A5046914597 @default.
• W1985191844 hasAuthorship W1985191844A5060352803 @default.
• W1985191844 hasAuthorship W1985191844A5067115806 @default.
• W1985191844 hasAuthorship W1985191844A5086064703 @default.
• W1985191844 hasBestOaLocation W19851918441 @default.
• W1985191844 hasConcept C104317684 @default.
• W1985191844 hasConcept C121608353 @default.
• W1985191844 hasConcept C134459356 @default.

• next