FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985196525> ?p ?o ?g. }

• W1985196525 endingPage "350" @default.
• W1985196525 startingPage "339" @default.
• W1985196525 abstract "Objective. Cell adhesion is an important cell survival determinant and disruption of integrin-mediated signal transduction may be involved in anchorage-dependent cell death. We have examined the processing of focal adhesion kinase (FAK), a component of integrin-mediated signal transduction, in a cisplatin-sensitive human ovarian epithelial cancer cell line (OV2008), to test the possible role of FAK degradation in the control of apoptosis via regulation of cell attachment. Methods. FAK processing after cisplatin treatment in the absence or presence of various caspase-inhibiting substances was analyzed by Western blot. Caspase-inhibiting activities were introduced using cell-permeable peptides or adenoviral vector. Results. Cisplatin-induced caspase 3 and FAK cleavage, cell detachment from the growth surface, and apoptosis in a temporally related and concentration-dependent manner. FAK fragments were detected exclusively in cells detached from the culture surface. Addition of active caspase 3 to the whole cell lysate elicited a similar pattern of FAK cleavage. Pretreatment of whole cell lysates and cells with tetrapeptide inhibitors of caspases significantly decreased FAK cleavage induced by exogenous active caspase 3 and cisplatin, respectively. Overexpression of X-linked inhibitor of apoptosis protein (Xiap), an endogenous caspase inhibitor, attenuated the cisplatin-induced FAK processing, morphologic changes, and apoptosis. The inhibitory action of Xiap was abolished with the deletion of a functional motif required for caspase inhibition. Conclusion. These findings are consistent with our hypothesis that FAK processing is in part mediated by caspase 3, the activation of which is modulated by Xiap." @default.
• W1985196525 created "2016-06-24" @default.
• W1985196525 creator A5013170437 @default.
• W1985196525 creator A5025447174 @default.
• W1985196525 creator A5028864429 @default.
• W1985196525 date "2002-05-01" @default.
• W1985196525 modified "2023-09-29" @default.
• W1985196525 title "Caspase 3-Mediated Focal Adhesion Kinase Processing in Human Ovarian Cancer Cells: Possible Regulation by X-Linked Inhibitor of Apoptosis Protein" @default.
• W1985196525 cites W1492302205 @default.
• W1985196525 cites W1557686543 @default.
• W1985196525 cites W168849662 @default.
• W1985196525 cites W1769479841 @default.
• W1985196525 cites W1966798559 @default.
• W1985196525 cites W1967120404 @default.
• W1985196525 cites W1969820174 @default.
• W1985196525 cites W1969943605 @default.
• W1985196525 cites W1976271632 @default.
• W1985196525 cites W1976570855 @default.
• W1985196525 cites W1978467605 @default.
• W1985196525 cites W1985210117 @default.
• W1985196525 cites W1992892839 @default.
• W1985196525 cites W1996807274 @default.
• W1985196525 cites W2006145157 @default.
• W1985196525 cites W2006892275 @default.
• W1985196525 cites W2010298858 @default.
• W1985196525 cites W2013801793 @default.
• W1985196525 cites W2014914858 @default.
• W1985196525 cites W2022362803 @default.
• W1985196525 cites W2025018535 @default.
• W1985196525 cites W2028691987 @default.
• W1985196525 cites W2029085695 @default.
• W1985196525 cites W2029962841 @default.
• W1985196525 cites W2030184878 @default.
• W1985196525 cites W2042409437 @default.
• W1985196525 cites W2045114648 @default.
• W1985196525 cites W2048666761 @default.
• W1985196525 cites W2049179639 @default.
• W1985196525 cites W2061497413 @default.
• W1985196525 cites W2075761806 @default.
• W1985196525 cites W2079930944 @default.
• W1985196525 cites W2083906562 @default.
• W1985196525 cites W2083957336 @default.
• W1985196525 cites W2084261874 @default.
• W1985196525 cites W2102369096 @default.
• W1985196525 cites W2104773672 @default.
• W1985196525 cites W2104979289 @default.
• W1985196525 cites W2116160463 @default.
• W1985196525 cites W2119222825 @default.
• W1985196525 cites W2120492514 @default.
• W1985196525 cites W2137022580 @default.
• W1985196525 cites W2150182870 @default.
• W1985196525 cites W2159695799 @default.
• W1985196525 cites W2162653594 @default.
• W1985196525 doi "https://doi.org/10.1006/gyno.2002.6632" @default.
• W1985196525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11972398" @default.
• W1985196525 hasPublicationYear "2002" @default.
• W1985196525 type Work @default.
• W1985196525 sameAs 1985196525 @default.
• W1985196525 citedByCount "33" @default.
• W1985196525 countsByYear W19851965252012 @default.
• W1985196525 countsByYear W19851965252013 @default.
• W1985196525 countsByYear W19851965252014 @default.
• W1985196525 countsByYear W19851965252017 @default.
• W1985196525 countsByYear W19851965252022 @default.
• W1985196525 crossrefType "journal-article" @default.
• W1985196525 hasAuthorship W1985196525A5013170437 @default.
• W1985196525 hasAuthorship W1985196525A5025447174 @default.
• W1985196525 hasAuthorship W1985196525A5028864429 @default.
• W1985196525 hasConcept C108391706 @default.
• W1985196525 hasConcept C121608353 @default.
• W1985196525 hasConcept C12519072 @default.
• W1985196525 hasConcept C1491633281 @default.
• W1985196525 hasConcept C151166631 @default.
• W1985196525 hasConcept C190283241 @default.
• W1985196525 hasConcept C195687474 @default.
• W1985196525 hasConcept C195794163 @default.
• W1985196525 hasConcept C2776694085 @default.
• W1985196525 hasConcept C2777408456 @default.
• W1985196525 hasConcept C2778239845 @default.
• W1985196525 hasConcept C31573885 @default.
• W1985196525 hasConcept C33195913 @default.
• W1985196525 hasConcept C48297814 @default.
• W1985196525 hasConcept C502942594 @default.
• W1985196525 hasConcept C54355233 @default.
• W1985196525 hasConcept C55493867 @default.
• W1985196525 hasConcept C62478195 @default.
• W1985196525 hasConcept C85789140 @default.
• W1985196525 hasConcept C86803240 @default.
• W1985196525 hasConcept C90934575 @default.
• W1985196525 hasConcept C95444343 @default.
• W1985196525 hasConcept C96232424 @default.
• W1985196525 hasConcept C98424977 @default.
• W1985196525 hasConceptScore W1985196525C108391706 @default.
• W1985196525 hasConceptScore W1985196525C121608353 @default.
• W1985196525 hasConceptScore W1985196525C12519072 @default.
• W1985196525 hasConceptScore W1985196525C1491633281 @default.
• W1985196525 hasConceptScore W1985196525C151166631 @default.
• W1985196525 hasConceptScore W1985196525C190283241 @default.

• next