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- W1985201903 abstract "Connexins (Cxs) are building unit proteins of gap junctions (GJs) that are prognostic markers in carcinomas. To investigate the role of Cx in Ewing sarcoma (EWS)/primitive neuroectodermal tumor (PNET), we examined the expression of Cx43 and Cx26 in 36 EWS/PNETs and found (1) cytoplasmic Cx43 reactivity in 28/36 (78%) cases. (2) Cx43 score was significantly correlated with overall survival (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.025</mml:mn></mml:mrow></mml:math>). The average scores for patients alive and dead at 3 years are 46.08 and 96.98 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.004</mml:mn></mml:mrow></mml:math>) at 5 years are 46.06 and 96.42 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.002</mml:mn></mml:mrow></mml:math>). (3) Metastasis had a significant effect on the overall survival (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.003</mml:mn></mml:mrow></mml:math>). (4) Cytoplasmic Cx26 reactivity was detected in 2 of 36 (6%) patients who died with metastasis. Our results suggest a possible oncogenic and prognostic role for Cx43 and Cx26 in EWS/PNET. The lack of membranous immunoreactivity suggests that the effect of Cx in EWS/PNET is via a GJ function-independent mechanism." @default.
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- W1985201903 date "2011-01-01" @default.
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- W1985201903 title "Connexin 43 Is a Potential Prognostic Biomarker for Ewing Sarcoma/Primitive Neuroectodermal Tumor" @default.
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- W1985201903 doi "https://doi.org/10.1155/2011/971050" @default.
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