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- W1985202261 endingPage "1119" @default.
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- W1985202261 abstract "Musculoskeletal injuries are the most common reason for operative procedures in severely injured patients and are major determinants of functional outcomes. In this paper, we summarise advances and future directions for management of multiply injured patients with major musculoskeletal trauma. Improved understanding of fracture healing has created new possibilities for management of particularly challenging problems, such as delayed union and non union of fractures and large bone defects. Optimum timing of major orthopaedic interventions is guided by increased knowledge about the immune response after injury. Individual treatment should be guided by trading off the benefits of early definitive skeletal stabilisation, and the potentially life-threatening risks of systemic complications such as fat embolism, acute lung injury, and multiple organ failure. New methods for measurement of fracture healing and function and quality of life outcomes pave the way for landmark trials that will guide the future management of musculoskeletal injuries. Musculoskeletal injuries are the most common reason for operative procedures in severely injured patients and are major determinants of functional outcomes. In this paper, we summarise advances and future directions for management of multiply injured patients with major musculoskeletal trauma. Improved understanding of fracture healing has created new possibilities for management of particularly challenging problems, such as delayed union and non union of fractures and large bone defects. Optimum timing of major orthopaedic interventions is guided by increased knowledge about the immune response after injury. Individual treatment should be guided by trading off the benefits of early definitive skeletal stabilisation, and the potentially life-threatening risks of systemic complications such as fat embolism, acute lung injury, and multiple organ failure. New methods for measurement of fracture healing and function and quality of life outcomes pave the way for landmark trials that will guide the future management of musculoskeletal injuries. Towards a maturation of trauma researchEvery year, almost 6 million people die and 100 million are admitted to hospital after traumatic injury.1 In most countries injury is the leading cause of death in people aged 45 years and younger. This injury burden leads to substantial lost productivity. By 2030, road traffic injuries are predicted to be the world's fifth leading cause of death and the third leading cause of disability.1 Full-Text PDF" @default.
- W1985202261 created "2016-06-24" @default.
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- W1985202261 date "2012-09-01" @default.
- W1985202261 modified "2023-10-17" @default.
- W1985202261 title "Advances and future directions for management of trauma patients with musculoskeletal injuries" @default.
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