Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985202473> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1985202473 endingPage "11" @default.
- W1985202473 startingPage "10" @default.
- W1985202473 abstract "Antiangiogenic approaches have been extensively exploited to provide a rationally designed therapy for the treatment of brain cancer. The brain tumor endothelium, with characteristics of high proliferation, high permeability, and high expression of proangiogenic factors (such as vascular endothelial growth factor, VEGF), is a particularly appealing therapeutic target for this strategy. Many antibody drugs, which primarily target the interaction between VEGF and its receptors, have been investigated in clinical trials but have shown only modest effects. Recent research published by Agemy et al.1 has alternatively harnessed a tumor-homing peptide (CGKRK) to specifically deliver multifunctional theranostic nanoparticles composed of iron oxide nanoworm (NW) and mitochondria-targeted cytotoxic peptide D[KLAKLAK]2 to glioblastoma multiforme (GBM) endothelium. Moreover, with the help of a tumor-penetrating peptide (iRGD), the NWs were capable of infiltrating the tumor tissue after extravasation for tumor cell eradication. This strategy was evaluated in lentivirus-induced, transplantable, and orthotopic brain tumor models. Complete tumor ablation was achieved in the first model and significant prolongation of survival was observed in the latter two models, suggesting promise for eventual clinical application." @default.
- W1985202473 created "2016-06-24" @default.
- W1985202473 creator A5004716253 @default.
- W1985202473 creator A5018222046 @default.
- W1985202473 date "2012-01-01" @default.
- W1985202473 modified "2023-10-11" @default.
- W1985202473 title "Multifunctional Theranostic Nanoparticles for Brain Tumors" @default.
- W1985202473 cites W1587050401 @default.
- W1985202473 cites W1966125619 @default.
- W1985202473 cites W1978041336 @default.
- W1985202473 cites W2037044453 @default.
- W1985202473 cites W2041617965 @default.
- W1985202473 cites W2100093425 @default.
- W1985202473 cites W2123647020 @default.
- W1985202473 cites W2168587151 @default.
- W1985202473 doi "https://doi.org/10.1038/mt.2011.274" @default.
- W1985202473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3255590" @default.
- W1985202473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22215053" @default.
- W1985202473 hasPublicationYear "2012" @default.
- W1985202473 type Work @default.
- W1985202473 sameAs 1985202473 @default.
- W1985202473 citedByCount "13" @default.
- W1985202473 countsByYear W19852024732012 @default.
- W1985202473 countsByYear W19852024732013 @default.
- W1985202473 countsByYear W19852024732014 @default.
- W1985202473 countsByYear W19852024732015 @default.
- W1985202473 countsByYear W19852024732016 @default.
- W1985202473 countsByYear W19852024732018 @default.
- W1985202473 countsByYear W19852024732020 @default.
- W1985202473 crossrefType "journal-article" @default.
- W1985202473 hasAuthorship W1985202473A5004716253 @default.
- W1985202473 hasAuthorship W1985202473A5018222046 @default.
- W1985202473 hasBestOaLocation W19852024731 @default.
- W1985202473 hasConcept C155672457 @default.
- W1985202473 hasConcept C171250308 @default.
- W1985202473 hasConcept C185592680 @default.
- W1985202473 hasConcept C192562407 @default.
- W1985202473 hasConcept C502942594 @default.
- W1985202473 hasConcept C71924100 @default.
- W1985202473 hasConceptScore W1985202473C155672457 @default.
- W1985202473 hasConceptScore W1985202473C171250308 @default.
- W1985202473 hasConceptScore W1985202473C185592680 @default.
- W1985202473 hasConceptScore W1985202473C192562407 @default.
- W1985202473 hasConceptScore W1985202473C502942594 @default.
- W1985202473 hasConceptScore W1985202473C71924100 @default.
- W1985202473 hasIssue "1" @default.
- W1985202473 hasLocation W19852024731 @default.
- W1985202473 hasLocation W19852024732 @default.
- W1985202473 hasLocation W19852024733 @default.
- W1985202473 hasLocation W19852024734 @default.
- W1985202473 hasOpenAccess W1985202473 @default.
- W1985202473 hasPrimaryLocation W19852024731 @default.
- W1985202473 hasRelatedWork W1066196250 @default.
- W1985202473 hasRelatedWork W1976195758 @default.
- W1985202473 hasRelatedWork W1977013938 @default.
- W1985202473 hasRelatedWork W2275341195 @default.
- W1985202473 hasRelatedWork W2314971351 @default.
- W1985202473 hasRelatedWork W2518360665 @default.
- W1985202473 hasRelatedWork W2899084033 @default.
- W1985202473 hasRelatedWork W3016721682 @default.
- W1985202473 hasRelatedWork W4248400276 @default.
- W1985202473 hasRelatedWork W4308033632 @default.
- W1985202473 hasVolume "20" @default.
- W1985202473 isParatext "false" @default.
- W1985202473 isRetracted "false" @default.
- W1985202473 magId "1985202473" @default.
- W1985202473 workType "article" @default.