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- W1985207229 abstract "There is a large and increasing body of experimental and clinical data supporting the existence of variant estrogen receptor (ER) proteins in both normal and neoplastic estrogen target tissues, including human breast. Therefore, future examination of ER signal transduction and/or measurement of ER protein must take into account variant ER expression. The functions of variant ER proteins, either physiological or pathological, remain unclear, although a role(s) for some ER variants in breast tumorigenesis and breast cancer progression would be consistent with the accumulated data. Possible tissue specific expression leads to the speculation that ER variants may have a role in tissue specific estrogen action. The following review focuses on the current knowledge available in the scientific literature with respect to the type and characteristics of estrogen receptor variants and mutations that have been identified to occur naturally in tissues and cell lines." @default.
- W1985207229 created "2016-06-24" @default.
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- W1985207229 date "1997-08-01" @default.
- W1985207229 modified "2023-09-27" @default.
- W1985207229 title "Estrogen receptor variants and mutations" @default.
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- W1985207229 doi "https://doi.org/10.1016/s0960-0760(97)00084-8" @default.
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