Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985211091> ?p ?o ?g. }
- W1985211091 endingPage "1188" @default.
- W1985211091 startingPage "1172" @default.
- W1985211091 abstract "Abstract Identification of gene expression changes that promote focal neuronal death and neurological dysfunction can further our understanding of the pathophysiology of these disease states and could lead to new pharmacological and molecular therapies. Impairment of oxidative metabolism is a pathogenetic mechanism underlying neuronal death in many chronic neurodegenerative diseases as well as in Wernicke's encephalopathy (WE), a disorder induced by thiamine deficiency (TD). To identify functional pathways that lead to neuronal damage in this disorder, we have examined gene expression changes in the vulnerable thalamus and inferior colliculus of TD rats using Affymetrix Rat Genome GeneChip analysis in combination with gene ontology and functional categorization assessment utilizing the NetAffx GO Mining Tool. Of the 15 927 transcripts analysed, 125 in thalamus and 141 in inferior colliculus were more abundantly expressed in TD rats compared with control animals. In both regions, the major functional categories of transcripts that were increased in abundance after TD were those associated with inflammation (∼33%), stress (∼20%), cell death and repair (∼26%), and metabolic perturbation (∼19%), together constituting ∼98% of all transcripts up‐regulated. These changes occurred against a background of neuronal cell loss and reactive astro‐ and microgliosis in both structures. Our results indicate that (i) TD produces changes in gene expression that are consistent with the observed dysfunction and pathology, and (ii) similar alterations in expression occur in thalamus and inferior colliculus, brain regions previously considered to differ in pathology. These findings provide important new insight into processes responsible for lesion development in TD, and possibly WE." @default.
- W1985211091 created "2016-06-24" @default.
- W1985211091 creator A5006041389 @default.
- W1985211091 creator A5016653284 @default.
- W1985211091 creator A5040264861 @default.
- W1985211091 creator A5043272107 @default.
- W1985211091 creator A5069187410 @default.
- W1985211091 date "2006-03-01" @default.
- W1985211091 modified "2023-10-16" @default.
- W1985211091 title "Gene expression changes in thalamus and inferior colliculus associated with inflammation, cellular stress, metabolism and structural damage in thiamine deficiency" @default.
- W1985211091 cites W1487196831 @default.
- W1985211091 cites W1489257403 @default.
- W1985211091 cites W1566540765 @default.
- W1985211091 cites W1597754875 @default.
- W1985211091 cites W1747473629 @default.
- W1985211091 cites W1940873540 @default.
- W1985211091 cites W1966105735 @default.
- W1985211091 cites W1967721753 @default.
- W1985211091 cites W1970273157 @default.
- W1985211091 cites W1970466917 @default.
- W1985211091 cites W1970941517 @default.
- W1985211091 cites W1982068556 @default.
- W1985211091 cites W1983584376 @default.
- W1985211091 cites W1983682043 @default.
- W1985211091 cites W1987439965 @default.
- W1985211091 cites W1988694547 @default.
- W1985211091 cites W1991017405 @default.
- W1985211091 cites W1991827413 @default.
- W1985211091 cites W2002472831 @default.
- W1985211091 cites W2004573685 @default.
- W1985211091 cites W2004656689 @default.
- W1985211091 cites W2008004827 @default.
- W1985211091 cites W2012710118 @default.
- W1985211091 cites W2015437585 @default.
- W1985211091 cites W2016621366 @default.
- W1985211091 cites W2019525505 @default.
- W1985211091 cites W2020941408 @default.
- W1985211091 cites W2024375726 @default.
- W1985211091 cites W2025676338 @default.
- W1985211091 cites W2028192143 @default.
- W1985211091 cites W2029276286 @default.
- W1985211091 cites W2030848377 @default.
- W1985211091 cites W2031054440 @default.
- W1985211091 cites W2031578583 @default.
- W1985211091 cites W2033521715 @default.
- W1985211091 cites W2035275513 @default.
- W1985211091 cites W2042379312 @default.
- W1985211091 cites W2048269882 @default.
- W1985211091 cites W2055785462 @default.
- W1985211091 cites W2061494834 @default.
- W1985211091 cites W2062745363 @default.
- W1985211091 cites W2064172252 @default.
- W1985211091 cites W2065601509 @default.
- W1985211091 cites W2070630858 @default.
- W1985211091 cites W2077240963 @default.
- W1985211091 cites W2079311820 @default.
- W1985211091 cites W2084533699 @default.
- W1985211091 cites W2088302893 @default.
- W1985211091 cites W2090223182 @default.
- W1985211091 cites W2091681614 @default.
- W1985211091 cites W2092560020 @default.
- W1985211091 cites W2094458559 @default.
- W1985211091 cites W2096000142 @default.
- W1985211091 cites W2104500108 @default.
- W1985211091 cites W2114729479 @default.
- W1985211091 cites W2122289231 @default.
- W1985211091 cites W2128879640 @default.
- W1985211091 cites W2130688891 @default.
- W1985211091 cites W2132480056 @default.
- W1985211091 cites W2142197498 @default.
- W1985211091 cites W2142775406 @default.
- W1985211091 cites W2146540226 @default.
- W1985211091 cites W2153364643 @default.
- W1985211091 cites W2159995582 @default.
- W1985211091 cites W2166431178 @default.
- W1985211091 cites W2169725606 @default.
- W1985211091 cites W2171605423 @default.
- W1985211091 cites W2291459728 @default.
- W1985211091 cites W1985925033 @default.
- W1985211091 doi "https://doi.org/10.1111/j.1460-9568.2006.04651.x" @default.
- W1985211091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16553781" @default.
- W1985211091 hasPublicationYear "2006" @default.
- W1985211091 type Work @default.
- W1985211091 sameAs 1985211091 @default.
- W1985211091 citedByCount "41" @default.
- W1985211091 countsByYear W19852110912012 @default.
- W1985211091 countsByYear W19852110912013 @default.
- W1985211091 countsByYear W19852110912014 @default.
- W1985211091 countsByYear W19852110912016 @default.
- W1985211091 countsByYear W19852110912017 @default.
- W1985211091 countsByYear W19852110912018 @default.
- W1985211091 countsByYear W19852110912019 @default.
- W1985211091 countsByYear W19852110912020 @default.
- W1985211091 countsByYear W19852110912021 @default.
- W1985211091 countsByYear W19852110912022 @default.
- W1985211091 crossrefType "journal-article" @default.
- W1985211091 hasAuthorship W1985211091A5006041389 @default.
- W1985211091 hasAuthorship W1985211091A5016653284 @default.