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- W1985217624 abstract "A total of 45 chemical substances have been tested as substrates for melanogenesis identified by pigment formation in melanocytes of freshly plucked hair roots incubated in 1 mM solutions of the compounds. Melanocytes of human red and blond hair and of guinea-pig red-blond hair can utilize eatechol, tyrosine, dopa, and 14 of their derivatives as substrates for pigment formation. Melanocytes of human red and blond hair, but not guinea-pig red-blond hairs form pigment from dopamine and methyl dopa. Human and guinea-pig hair melanocytes form dark brown pigments from dopa, dopa methyl ester, and dopamine; lighter brown pigments from tyrosine, eatechol, dopa ethyl ester, dopa n-propyl ester, and dopa n-butyl ester; and golden yellow pigments from dopa isopropyl and isoamyl esters. Identification of the substrates utilized for melanogenesis may provide new clues to possible means of specifically affecting melanocyte function." @default.
- W1985217624 created "2016-06-24" @default.
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- W1985217624 date "1973-04-01" @default.
- W1985217624 modified "2023-09-26" @default.
- W1985217624 title "Substrate Identity in Mammalian Melanogenesis" @default.
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- W1985217624 doi "https://doi.org/10.1111/1523-1747.ep12724529" @default.
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