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- W198522014 abstract "Antibodies directed toward the antitumor protein neocarzinostatin (NCS) have been produced in a rabbit by immunization with a highly purified NCS preparation. The antiserum was monospecific and reversed the antibacterial activity of NCS against Sarcina lutea. It cross-reacted with chemically modified derivatives of NCS and mitomalcin but failed to cross-react with macromomycin. A radioimmunoassay procedure has been developed utilizing the antiserum and a biologically active 125I-labeled derivative of NCS. The lower limit of detection by this radioimmunoassay, which involves a double antibody technique for the separation of antibody-bound and free antigen, was 1 X 10(-13) mole. The sensitivity of the assay is such that serum levels of NCS can be determined accurately after administration of the drug to rats at a single dose of 2 mg/kg. Since NCS is now undergoing clinical trial, the radioimmunoassay of the drug will be a valuable tool in clinical pharmacological studies." @default.
- W198522014 created "2016-06-24" @default.
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- W198522014 date "1976-12-01" @default.
- W198522014 modified "2023-09-26" @default.
- W198522014 title "Radioimmunoassay of neocarzinostatin, an antitumor protein. [/sup 125/I tracer technique, rats]" @default.
- W198522014 hasPublicationYear "1976" @default.
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