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• W1985223791 abstract "The relationship between Fas -1377 G/A polymorphism and cancer susceptibility has been implicated in accumulating data. However, the data presented inconsistent results. This study was devised to investigate the association of Fas -1377 G/A polymorphism and cancer susceptibility in a large number of participants.The databases of PubMed, Embase, and Web of Science were searched and a total of 27 case-control studies including 13,355 cases and 16,078 controls were included in this meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the fixed-effects model. Statistical analyses were performed by using Stata software.The results suggested that Fas -1377 G/A polymorphism was overall associated with cancer susceptibility (additive model: OR, 1.16, 95%CI = 1.06-1.27, Pheterogeneity = 0.381; recessive model: OR, 1.19, 95%CI = 1.10-1.29, Pheterogeneity= 0.137). In the subgroup analysis by cancer type, significantly increased risk was observed in breast cancer (additive model: OR, 1.24, 95%CI = 1.04-1.58, Pheterogeneity = 0.614; recessive model: OR, 1.24, 95%CI = 1.02-1.51, Pheterogeneity = 0.349) and lung cancer (recessive model: OR, 1.25, 95%CI = 1.04-1.49, Pheterogeneity = 0.090). Similarly, elevated cancer risk associated with Fas -1377 G/A polymorphism was revealed in Asians.The combined results suggest that Fas -1377 G/A polymorphism might modulate cancer susceptibility in an Asian-specific manner." @default.
• W1985223791 created "2016-06-24" @default.
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• W1985223791 date "2014-02-18" @default.
• W1985223791 modified "2023-10-16" @default.
• W1985223791 title "Association of Fas -1377 G/A Polymorphism with Susceptibility to Cancer" @default.
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• W1985223791 doi "https://doi.org/10.1371/journal.pone.0088748" @default.
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