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• W1985236314 abstract "Tuberculosis (TB) is a serious world-wide health problem, causing millions of deaths every year. Metabolomics is a relatively new approach to identify disease specific biomarkers. However, there is little information available on metabolite biomarkers in TB. In this study, we used gas chromatography/time-of-flight mass spectrometry (GC/TOF-MS) to identify serum metabolite biomarkers associated with the active state of TB. Potential biomarkers were selected by comparing serum metabolites in 10 healthy donors with 10 TB patients, and in 6 TB patients before and after treatment. Selected biomarkers were then validated using a larger population of samples from 120 healthy donors and 120 TB patients derived from different clinical backgrounds The 5-oxoproline level was consistently low in patients with active TB. Further validation in larger population of clinical samples showed that 5-oxoproline was associated with pathological damage of the lung but not with age, sex, or bacterial burden in TB patients. Serum 5-oxoproline may be a useful biomarker for active TB and pathological damage of the lung." @default.
• W1985236314 created "2016-06-24" @default.
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• W1985236314 date "2013-08-01" @default.
• W1985236314 modified "2023-10-18" @default.
• W1985236314 title "Decreased serum 5-oxoproline in TB patients is associated with pathological damage of the lung" @default.
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• W1985236314 doi "https://doi.org/10.1016/j.cca.2013.04.010" @default.
• W1985236314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23608301" @default.
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