FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985242005> ?p ?o ?g. }

• W1985242005 endingPage "66" @default.
• W1985242005 startingPage "61" @default.
• W1985242005 abstract "Antimicrobial peptides produced by epithelial cells represent essential elements of innate immunity. Human β-defensin-2 (hβD-2) is a major inducible antimicrobial peptide which plays an important role in host defense. The goal of this study was to determine the effect of Mycobacterium bovis bacillus Calmette-Guérin (BCG) on hβD-2 gene expression in epithelial cells, and to characterize further the signaling pathways involved in hβD-2 induction in response to M. bovis BCG. Using reverse transcription-polymerase chain reaction (RT-PCR), hβD-2 mRNA expression was detected in pulmonary epithelial cells infected with M. bovis BCG. Furthermore, we found that M. bovis BCG-induced hβD-2 mRNA expression was sustained by endogenous TNF-α in A549 cells. Of note, hβD-2 induction by M. bovis BCG was not blocked by pretreatment with anti-IL6 antibody. Moreover, hβD-2 mRNA expression was regulated at a transcriptional level, since hβD-2 induction by M. bovis BCG was blocked by two inhibitors of NF-κB. Taken together, these results suggest that M. bovis BCG infection of human epithelial cells induces hβD-2 mRNA expression which is up-regulated by TNF-α produced from M. bovis BCG-infected cells, and is modulated by NF-κB. Studies of hβD-2 mRNA regulation in epithelial cells infected with M. bovis BCG provide insight into how its expression may be enhanced to control Mycobacterium tuberculosis infection." @default.
• W1985242005 created "2016-06-24" @default.
• W1985242005 creator A5000903764 @default.
• W1985242005 creator A5068703971 @default.
• W1985242005 creator A5082063678 @default.
• W1985242005 date "2006-01-01" @default.
• W1985242005 modified "2023-10-03" @default.
• W1985242005 title "Mycobacterium bovis Bacillus Calmette-Guérin (BCG) stimulates human β-defensin-2 gene transcription in human epithelial cells" @default.
• W1985242005 cites W1521868200 @default.
• W1985242005 cites W1836294001 @default.
• W1985242005 cites W1985243691 @default.
• W1985242005 cites W1986362742 @default.
• W1985242005 cites W1986923265 @default.
• W1985242005 cites W1987150557 @default.
• W1985242005 cites W199132020 @default.
• W1985242005 cites W1995053645 @default.
• W1985242005 cites W1997942004 @default.
• W1985242005 cites W2011842440 @default.
• W1985242005 cites W2065273951 @default.
• W1985242005 cites W2067539471 @default.
• W1985242005 cites W2093412162 @default.
• W1985242005 cites W2104159258 @default.
• W1985242005 cites W2120159718 @default.
• W1985242005 cites W2122270915 @default.
• W1985242005 cites W2130765682 @default.
• W1985242005 cites W2134912543 @default.
• W1985242005 cites W2141632987 @default.
• W1985242005 cites W2143303543 @default.
• W1985242005 cites W2145078103 @default.
• W1985242005 cites W2158789628 @default.
• W1985242005 cites W2164479055 @default.
• W1985242005 cites W2167925233 @default.
• W1985242005 cites W2170442599 @default.
• W1985242005 cites W2171230459 @default.
• W1985242005 cites W4255469779 @default.
• W1985242005 cites W4312427153 @default.
• W1985242005 cites W49625740 @default.
• W1985242005 doi "https://doi.org/10.1016/j.cellimm.2006.04.001" @default.
• W1985242005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16762333" @default.
• W1985242005 hasPublicationYear "2006" @default.
• W1985242005 type Work @default.
• W1985242005 sameAs 1985242005 @default.
• W1985242005 citedByCount "28" @default.
• W1985242005 countsByYear W19852420052012 @default.
• W1985242005 countsByYear W19852420052013 @default.
• W1985242005 countsByYear W19852420052014 @default.
• W1985242005 countsByYear W19852420052015 @default.
• W1985242005 countsByYear W19852420052016 @default.
• W1985242005 countsByYear W19852420052017 @default.
• W1985242005 countsByYear W19852420052018 @default.
• W1985242005 countsByYear W19852420052019 @default.
• W1985242005 countsByYear W19852420052020 @default.
• W1985242005 countsByYear W19852420052021 @default.
• W1985242005 countsByYear W19852420052023 @default.
• W1985242005 crossrefType "journal-article" @default.
• W1985242005 hasAuthorship W1985242005A5000903764 @default.
• W1985242005 hasAuthorship W1985242005A5068703971 @default.
• W1985242005 hasAuthorship W1985242005A5082063678 @default.
• W1985242005 hasConcept C104317684 @default.
• W1985242005 hasConcept C105580179 @default.
• W1985242005 hasConcept C129437159 @default.
• W1985242005 hasConcept C136449434 @default.
• W1985242005 hasConcept C142724271 @default.
• W1985242005 hasConcept C150194340 @default.
• W1985242005 hasConcept C153911025 @default.
• W1985242005 hasConcept C203014093 @default.
• W1985242005 hasConcept C2776498113 @default.
• W1985242005 hasConcept C2777975735 @default.
• W1985242005 hasConcept C2778497218 @default.
• W1985242005 hasConcept C2781069245 @default.
• W1985242005 hasConcept C4937899 @default.
• W1985242005 hasConcept C54355233 @default.
• W1985242005 hasConcept C55493867 @default.
• W1985242005 hasConcept C71924100 @default.
• W1985242005 hasConcept C81729549 @default.
• W1985242005 hasConcept C81885089 @default.
• W1985242005 hasConcept C86803240 @default.
• W1985242005 hasConcept C8891405 @default.
• W1985242005 hasConcept C89423630 @default.
• W1985242005 hasConceptScore W1985242005C104317684 @default.
• W1985242005 hasConceptScore W1985242005C105580179 @default.
• W1985242005 hasConceptScore W1985242005C129437159 @default.
• W1985242005 hasConceptScore W1985242005C136449434 @default.
• W1985242005 hasConceptScore W1985242005C142724271 @default.
• W1985242005 hasConceptScore W1985242005C150194340 @default.
• W1985242005 hasConceptScore W1985242005C153911025 @default.
• W1985242005 hasConceptScore W1985242005C203014093 @default.
• W1985242005 hasConceptScore W1985242005C2776498113 @default.
• W1985242005 hasConceptScore W1985242005C2777975735 @default.
• W1985242005 hasConceptScore W1985242005C2778497218 @default.
• W1985242005 hasConceptScore W1985242005C2781069245 @default.
• W1985242005 hasConceptScore W1985242005C4937899 @default.
• W1985242005 hasConceptScore W1985242005C54355233 @default.
• W1985242005 hasConceptScore W1985242005C55493867 @default.
• W1985242005 hasConceptScore W1985242005C71924100 @default.
• W1985242005 hasConceptScore W1985242005C81729549 @default.
• W1985242005 hasConceptScore W1985242005C81885089 @default.
• W1985242005 hasConceptScore W1985242005C86803240 @default.

• next