FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985243417> ?p ?o ?g. }

• W1985243417 endingPage "551" @default.
• W1985243417 startingPage "545" @default.
• W1985243417 abstract "Variation in the renin-angiotensin system (RAS) and salt-sensitivity genes may influence the effect of thiazides on the risk of diabetes. We assessed whether polymorphisms in RAS and salt-sensitivity genes influenced the risk of diabetes associated with thiazides.Nested case-control study was conducted among antihypertensive drug users. Pharmacy records and questionnaires were used to assess new onset diabetes (cases), to ascertain antihypertensive use and risk factors for diabetes. Cases were matched to controls (up to five) who were not (yet) diagnosed with diabetes mellitus. We genotyped angiotensin-converting enzyme (ACE) (G4656C), angiotensinogen (AGT) (M235T), angiotensin II type 1 receptor, (AGTR1) (A1166C), adducin 1 (alpha) (ADD1) (G460T), guanine nucleotide binding protein (G protein), beta-polypeptide 3 (GNB3) (C825T).Among 497 incident cases of type 2 diabetes and 2,633 controls, AGTR1 CC genotype carriers had no increased risk of diabetes due to thiazides (odds ratio (OR) 0.63 (95% confidence interval (CI): 0.28-1.40)) compared to AGTR1 1166A allele carriers (OR 1.79 (95% CI: 1.43-2.23)) receiving thiazides (synergy index (SI) for interaction 0.32 (95% CI: 0.15-0.68)). Although homozygous ACE GG subjects and ACE C allele carriers both had an increased risk of diabetes associated with thiazide use, this risk was more increased for ACE GG subjects (SI 1.70 (95% CI: 1.08-2.66)), particularly at doses > or =1 daily defined dose (DDD) (=25 mg hydrochlorothiazide)/day (SI 2.0 (95% CI: 1.20-3.32)). Among GNB3 T allele carriers, the risk of diabetes due to thiazide use was less increased than among homozygous GNB3 CC subjects (SI 0.62 (95% CI: 0.41-0.93)).The risk of diabetes due to thiazide use was not increased among AGTR1 1166 CC homozygous subjects and less increased among GNB3 T allele carriers. The ACE 4656 GG genotype enhanced the risk of diabetes due to thiazides." @default.
• W1985243417 created "2016-06-24" @default.
• W1985243417 creator A5016074663 @default.
• W1985243417 creator A5029747856 @default.
• W1985243417 creator A5038962814 @default.
• W1985243417 creator A5051358645 @default.
• W1985243417 creator A5058786461 @default.
• W1985243417 creator A5065212821 @default.
• W1985243417 creator A5077437482 @default.
• W1985243417 date "2009-05-01" @default.
• W1985243417 modified "2023-09-26" @default.
• W1985243417 title "Variation in Renin-Angiotensin System and Salt-Sensitivity Genes and the Risk of Diabetes Mellitus Associated With the Use of Thiazide Diuretics" @default.
• W1985243417 cites W1995973057 @default.
• W1985243417 cites W2011532294 @default.
• W1985243417 cites W2011685002 @default.
• W1985243417 cites W2016898079 @default.
• W1985243417 cites W2025057923 @default.
• W1985243417 cites W2030578633 @default.
• W1985243417 cites W2051491014 @default.
• W1985243417 cites W2065825768 @default.
• W1985243417 cites W2067372079 @default.
• W1985243417 cites W2092289093 @default.
• W1985243417 cites W2094856129 @default.
• W1985243417 cites W2102697854 @default.
• W1985243417 cites W2106648861 @default.
• W1985243417 cites W2108959130 @default.
• W1985243417 cites W2124269158 @default.
• W1985243417 cites W2134293572 @default.
• W1985243417 cites W2142937102 @default.
• W1985243417 cites W2157565919 @default.
• W1985243417 cites W2157983429 @default.
• W1985243417 cites W2159854507 @default.
• W1985243417 cites W2322402381 @default.
• W1985243417 doi "https://doi.org/10.1038/ajh.2009.38" @default.
• W1985243417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19247266" @default.
• W1985243417 hasPublicationYear "2009" @default.
• W1985243417 type Work @default.
• W1985243417 sameAs 1985243417 @default.
• W1985243417 citedByCount "26" @default.
• W1985243417 countsByYear W19852434172012 @default.
• W1985243417 countsByYear W19852434172013 @default.
• W1985243417 countsByYear W19852434172014 @default.
• W1985243417 countsByYear W19852434172015 @default.
• W1985243417 countsByYear W19852434172016 @default.
• W1985243417 countsByYear W19852434172018 @default.
• W1985243417 countsByYear W19852434172019 @default.
• W1985243417 countsByYear W19852434172020 @default.
• W1985243417 countsByYear W19852434172023 @default.
• W1985243417 crossrefType "journal-article" @default.
• W1985243417 hasAuthorship W1985243417A5016074663 @default.
• W1985243417 hasAuthorship W1985243417A5029747856 @default.
• W1985243417 hasAuthorship W1985243417A5038962814 @default.
• W1985243417 hasAuthorship W1985243417A5051358645 @default.
• W1985243417 hasAuthorship W1985243417A5058786461 @default.
• W1985243417 hasAuthorship W1985243417A5065212821 @default.
• W1985243417 hasAuthorship W1985243417A5077437482 @default.
• W1985243417 hasBestOaLocation W19852434171 @default.
• W1985243417 hasConcept C104317684 @default.
• W1985243417 hasConcept C126322002 @default.
• W1985243417 hasConcept C134018914 @default.
• W1985243417 hasConcept C156957248 @default.
• W1985243417 hasConcept C180754005 @default.
• W1985243417 hasConcept C2777180221 @default.
• W1985243417 hasConcept C2779918671 @default.
• W1985243417 hasConcept C2780361556 @default.
• W1985243417 hasConcept C2780437262 @default.
• W1985243417 hasConcept C54355233 @default.
• W1985243417 hasConcept C555293320 @default.
• W1985243417 hasConcept C71924100 @default.
• W1985243417 hasConcept C84393581 @default.
• W1985243417 hasConcept C86803240 @default.
• W1985243417 hasConceptScore W1985243417C104317684 @default.
• W1985243417 hasConceptScore W1985243417C126322002 @default.
• W1985243417 hasConceptScore W1985243417C134018914 @default.
• W1985243417 hasConceptScore W1985243417C156957248 @default.
• W1985243417 hasConceptScore W1985243417C180754005 @default.
• W1985243417 hasConceptScore W1985243417C2777180221 @default.
• W1985243417 hasConceptScore W1985243417C2779918671 @default.
• W1985243417 hasConceptScore W1985243417C2780361556 @default.
• W1985243417 hasConceptScore W1985243417C2780437262 @default.
• W1985243417 hasConceptScore W1985243417C54355233 @default.
• W1985243417 hasConceptScore W1985243417C555293320 @default.
• W1985243417 hasConceptScore W1985243417C71924100 @default.
• W1985243417 hasConceptScore W1985243417C84393581 @default.
• W1985243417 hasConceptScore W1985243417C86803240 @default.
• W1985243417 hasIssue "5" @default.
• W1985243417 hasLocation W19852434171 @default.
• W1985243417 hasLocation W19852434172 @default.
• W1985243417 hasOpenAccess W1985243417 @default.
• W1985243417 hasPrimaryLocation W19852434171 @default.
• W1985243417 hasRelatedWork W1966504330 @default.
• W1985243417 hasRelatedWork W1979139803 @default.
• W1985243417 hasRelatedWork W1998267900 @default.
• W1985243417 hasRelatedWork W2037631372 @default.
• W1985243417 hasRelatedWork W2040058909 @default.
• W1985243417 hasRelatedWork W2086673831 @default.
• W1985243417 hasRelatedWork W2107113359 @default.
• W1985243417 hasRelatedWork W2138029694 @default.

• next