FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985255104> ?p ?o ?g. }

• W1985255104 endingPage "15" @default.
• W1985255104 startingPage "10" @default.
• W1985255104 abstract "The clinical and hematological response to hydroxyurea was evaluated in β thalassemia patients in western India with variable clinical severity and correlated with genetic factors. Seventy-nine patients-[38-β thalassemia intermedia-(group I), 41-β thalassemia major-(group II)] on hydroxyurea therapy were followed-up for 20–24 months. Among the frequently transfused patients in group I, 58% became transfusion independent and 16% showed a 50% reduction in transfusions after therapy which correlated with a higher mean fold increase in HbF and γ mRNA expression levels. Forty-one percent of patients in group I had associated α-thalassemia and 72.7% were XmnI (+/+). β thalassemia chromosomes among the responders of group I (41%) were linked to haplotype (− + + − + + − − +) as against haplotype (+ − − − − − − − +) being more common among the non-responders. Response was not linked to the β thalassemia mutations. Thirty-two percent of group II patients showed a 50% reduction in their transfusion requirements after therapy which also correlated with a higher mean fold increase in HbF and γ mRNA expression levels. A significant decrease in serum ferritin was seen in both groups. 19% of patients could not tolerate the drug. In group I, clinical response to hydroxyurea was better in patients with α–thalassemia, XmnI (+/+) and a higher mean fold increase in γ mRNA expression. In group II, only one-third of patients showed a partial response." @default.
• W1985255104 created "2016-06-24" @default.
• W1985255104 creator A5007775762 @default.
• W1985255104 creator A5017334160 @default.
• W1985255104 creator A5017913326 @default.
• W1985255104 creator A5031782697 @default.
• W1985255104 creator A5039672267 @default.
• W1985255104 creator A5042624147 @default.
• W1985255104 creator A5059146350 @default.
• W1985255104 creator A5060219108 @default.
• W1985255104 creator A5085573485 @default.
• W1985255104 date "2009-09-01" @default.
• W1985255104 modified "2023-09-27" @default.
• W1985255104 title "Response to hydroxyurea in β thalassemia major and intermedia: Experience in western India" @default.
• W1985255104 cites W1992828384 @default.
• W1985255104 cites W1993847169 @default.
• W1985255104 cites W2001926054 @default.
• W1985255104 cites W2002124397 @default.
• W1985255104 cites W2004203135 @default.
• W1985255104 cites W2007705310 @default.
• W1985255104 cites W2012661184 @default.
• W1985255104 cites W2015378087 @default.
• W1985255104 cites W2045864610 @default.
• W1985255104 cites W2046042205 @default.
• W1985255104 cites W2051610861 @default.
• W1985255104 cites W2057896284 @default.
• W1985255104 cites W206006204 @default.
• W1985255104 cites W2070691466 @default.
• W1985255104 cites W2073274964 @default.
• W1985255104 cites W2087657427 @default.
• W1985255104 cites W2090093667 @default.
• W1985255104 cites W2131678910 @default.
• W1985255104 cites W2143146123 @default.
• W1985255104 cites W2143567367 @default.
• W1985255104 cites W2147640835 @default.
• W1985255104 cites W2155345859 @default.
• W1985255104 cites W2313541759 @default.
• W1985255104 cites W2436903794 @default.
• W1985255104 cites W267386141 @default.
• W1985255104 cites W4302354217 @default.
• W1985255104 doi "https://doi.org/10.1016/j.cca.2009.06.019" @default.
• W1985255104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19545554" @default.
• W1985255104 hasPublicationYear "2009" @default.
• W1985255104 type Work @default.
• W1985255104 sameAs 1985255104 @default.
• W1985255104 citedByCount "64" @default.
• W1985255104 countsByYear W19852551042012 @default.
• W1985255104 countsByYear W19852551042013 @default.
• W1985255104 countsByYear W19852551042014 @default.
• W1985255104 countsByYear W19852551042015 @default.
• W1985255104 countsByYear W19852551042016 @default.
• W1985255104 countsByYear W19852551042017 @default.
• W1985255104 countsByYear W19852551042018 @default.
• W1985255104 countsByYear W19852551042019 @default.
• W1985255104 countsByYear W19852551042020 @default.
• W1985255104 countsByYear W19852551042021 @default.
• W1985255104 countsByYear W19852551042022 @default.
• W1985255104 countsByYear W19852551042023 @default.
• W1985255104 crossrefType "journal-article" @default.
• W1985255104 hasAuthorship W1985255104A5007775762 @default.
• W1985255104 hasAuthorship W1985255104A5017334160 @default.
• W1985255104 hasAuthorship W1985255104A5017913326 @default.
• W1985255104 hasAuthorship W1985255104A5031782697 @default.
• W1985255104 hasAuthorship W1985255104A5039672267 @default.
• W1985255104 hasAuthorship W1985255104A5042624147 @default.
• W1985255104 hasAuthorship W1985255104A5059146350 @default.
• W1985255104 hasAuthorship W1985255104A5060219108 @default.
• W1985255104 hasAuthorship W1985255104A5085573485 @default.
• W1985255104 hasConcept C104317684 @default.
• W1985255104 hasConcept C126322002 @default.
• W1985255104 hasConcept C180754005 @default.
• W1985255104 hasConcept C197754878 @default.
• W1985255104 hasConcept C203014093 @default.
• W1985255104 hasConcept C2776175824 @default.
• W1985255104 hasConcept C2777799968 @default.
• W1985255104 hasConcept C2778319317 @default.
• W1985255104 hasConcept C2779668550 @default.
• W1985255104 hasConcept C2779817106 @default.
• W1985255104 hasConcept C2780014101 @default.
• W1985255104 hasConcept C3019184707 @default.
• W1985255104 hasConcept C54355233 @default.
• W1985255104 hasConcept C71924100 @default.
• W1985255104 hasConcept C86803240 @default.
• W1985255104 hasConcept C90924648 @default.
• W1985255104 hasConceptScore W1985255104C104317684 @default.
• W1985255104 hasConceptScore W1985255104C126322002 @default.
• W1985255104 hasConceptScore W1985255104C180754005 @default.
• W1985255104 hasConceptScore W1985255104C197754878 @default.
• W1985255104 hasConceptScore W1985255104C203014093 @default.
• W1985255104 hasConceptScore W1985255104C2776175824 @default.
• W1985255104 hasConceptScore W1985255104C2777799968 @default.
• W1985255104 hasConceptScore W1985255104C2778319317 @default.
• W1985255104 hasConceptScore W1985255104C2779668550 @default.
• W1985255104 hasConceptScore W1985255104C2779817106 @default.
• W1985255104 hasConceptScore W1985255104C2780014101 @default.
• W1985255104 hasConceptScore W1985255104C3019184707 @default.
• W1985255104 hasConceptScore W1985255104C54355233 @default.
• W1985255104 hasConceptScore W1985255104C71924100 @default.

• next