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- W1985255131 abstract "Abstract A recently developed pharmacokinetic model of the insulin-glucose system has been used to investigate the contribution of insulin-induced suppression of endogenous glucose production (EGP) to the hypoglycemic effect of insulin in the treatment of diabetic ketoacidosis and to determine the influence of the initial degree of hyperglycemia on the course of insulin treatment. Simulations of the time course of glucose concentration in the plasma following low-dose insulin therapy indicate that the hypoglycemic action of insulin is largely due to insulin-dependent glucose utilization and that suppression of EGP, if it occurs at all, contributes little to the overall effect. Nevertheless, a particularly useful characteristic of the pharmacokinetic model of the insulin-glucose system that assumes little or no suppression of EGP is its ability to predict glucose rebound when insulin has been effectively depleted. Other simulations reveal that the initial degree of hyperglycemia has little influence on the clinical outcome of low-dose insulin treatment of diabetic ketoacidosis. According to the simulation, 0.1 (U/kg)/hr intravenous infusion of insulin will produce satisfactory control of plasma glucose concentrations within 5–8 hr, assuming initial glucose concentrations ranging from 500 to 1500 mg/dl." @default.
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- W1985255131 date "1978-03-01" @default.
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- W1985255131 title "Pharmacokinetic studies of the hypoglycemic effects of insulin in the treatment of diabetic ketoacidosis" @default.
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- W1985255131 doi "https://doi.org/10.1016/0378-5173(78)90006-6" @default.
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