Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985255191> ?p ?o ?g. }
- W1985255191 endingPage "2833" @default.
- W1985255191 startingPage "2827" @default.
- W1985255191 abstract "Background: Low bone mineral density (BMD) is an emerging metabolic condition in HIV-infected patients; however, data on progression of this disease are scarce. Methods: We studied 671 patients with at least one dual-energy X-ray absorptiometry scan (391 of them ≥2 scans) to determine the prevalence and progression of BMD and establish related factors. Linear regression and logistic polytomic regression were used for the cross-sectional study and mixed effects and generalized estimating equations were used for the longitudinal study. Results: Osteopenia and osteoporosis were diagnosed in 47.5 and 23%, respectively. Progression to bone demineralization was observed in 28% of the patients over a median of 2.5 years (12.5% progressed to osteopenia and 15.6% to osteoporosis). In the 105 patients with at least 5 years of follow-up, progression was 47% (18% to osteopenia; 29% to osteoporosis). Factors associated with bone loss and progression were age [odds ratio (OR) 1.07; 95% confidence interval (CI) 1.05–1.08; P < 0.0001], male sex (OR 2.23; 95% CI 1.77–2.8; P < 0.0001), low body mass index (OR 1.14; 95% CI 1.11–1.17; P < 0.0001), time on protease inhibitor (OR 1.18; 95% CI 1.12–1.24; P < 0.0001), time on tenofovir (OR 1.08; 95% CI 1.03–1.14; P < 0.0019), and current use of protease inhibitors (OR 1.64; 95% CI 1.35–2.04; P < 0.0001). Conclusions: Our results show a high prevalence of and considerable progression to osteopenia/osteoporosis in our cohort. Our findings support the importance of applying adequate strategies to prevent bone demineralization and of close monitoring of BMD in HIV-infected patients, specifically in at-risk patients who are taking antiretrovirals that affect bone mineralization." @default.
- W1985255191 created "2016-06-24" @default.
- W1985255191 creator A5004612964 @default.
- W1985255191 creator A5028130303 @default.
- W1985255191 creator A5041525754 @default.
- W1985255191 creator A5048068703 @default.
- W1985255191 creator A5053925633 @default.
- W1985255191 creator A5064316951 @default.
- W1985255191 creator A5072805247 @default.
- W1985255191 creator A5077441779 @default.
- W1985255191 creator A5084333112 @default.
- W1985255191 creator A5085548936 @default.
- W1985255191 creator A5087975641 @default.
- W1985255191 date "2010-11-27" @default.
- W1985255191 modified "2023-10-17" @default.
- W1985255191 title "High prevalence of and progression to low bone mineral density in HIV-infected patients: a longitudinal cohort study" @default.
- W1985255191 cites W1497170016 @default.
- W1985255191 cites W1589406622 @default.
- W1985255191 cites W1970359693 @default.
- W1985255191 cites W1982990064 @default.
- W1985255191 cites W1990287212 @default.
- W1985255191 cites W1993015636 @default.
- W1985255191 cites W1995903292 @default.
- W1985255191 cites W1996313031 @default.
- W1985255191 cites W2006498349 @default.
- W1985255191 cites W2025683142 @default.
- W1985255191 cites W2025740330 @default.
- W1985255191 cites W2027372478 @default.
- W1985255191 cites W2032448658 @default.
- W1985255191 cites W2039415019 @default.
- W1985255191 cites W2056779298 @default.
- W1985255191 cites W2061555322 @default.
- W1985255191 cites W2062506737 @default.
- W1985255191 cites W2078677380 @default.
- W1985255191 cites W2085916903 @default.
- W1985255191 cites W2086774058 @default.
- W1985255191 cites W2086847415 @default.
- W1985255191 cites W2092392284 @default.
- W1985255191 cites W2093888975 @default.
- W1985255191 cites W2107789045 @default.
- W1985255191 cites W2110400973 @default.
- W1985255191 cites W2112636117 @default.
- W1985255191 cites W2125243069 @default.
- W1985255191 cites W2128513451 @default.
- W1985255191 cites W2130255770 @default.
- W1985255191 cites W2141098723 @default.
- W1985255191 cites W2144044201 @default.
- W1985255191 cites W2161193921 @default.
- W1985255191 cites W2168296515 @default.
- W1985255191 cites W2172226708 @default.
- W1985255191 doi "https://doi.org/10.1097/qad.0b013e328340a28d" @default.
- W1985255191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21045635" @default.
- W1985255191 hasPublicationYear "2010" @default.
- W1985255191 type Work @default.
- W1985255191 sameAs 1985255191 @default.
- W1985255191 citedByCount "146" @default.
- W1985255191 countsByYear W19852551912012 @default.
- W1985255191 countsByYear W19852551912013 @default.
- W1985255191 countsByYear W19852551912014 @default.
- W1985255191 countsByYear W19852551912015 @default.
- W1985255191 countsByYear W19852551912016 @default.
- W1985255191 countsByYear W19852551912017 @default.
- W1985255191 countsByYear W19852551912018 @default.
- W1985255191 countsByYear W19852551912019 @default.
- W1985255191 countsByYear W19852551912020 @default.
- W1985255191 countsByYear W19852551912021 @default.
- W1985255191 countsByYear W19852551912022 @default.
- W1985255191 countsByYear W19852551912023 @default.
- W1985255191 crossrefType "journal-article" @default.
- W1985255191 hasAuthorship W1985255191A5004612964 @default.
- W1985255191 hasAuthorship W1985255191A5028130303 @default.
- W1985255191 hasAuthorship W1985255191A5041525754 @default.
- W1985255191 hasAuthorship W1985255191A5048068703 @default.
- W1985255191 hasAuthorship W1985255191A5053925633 @default.
- W1985255191 hasAuthorship W1985255191A5064316951 @default.
- W1985255191 hasAuthorship W1985255191A5072805247 @default.
- W1985255191 hasAuthorship W1985255191A5077441779 @default.
- W1985255191 hasAuthorship W1985255191A5084333112 @default.
- W1985255191 hasAuthorship W1985255191A5085548936 @default.
- W1985255191 hasAuthorship W1985255191A5087975641 @default.
- W1985255191 hasConcept C126322002 @default.
- W1985255191 hasConcept C156957248 @default.
- W1985255191 hasConcept C2776541429 @default.
- W1985255191 hasConcept C2776886416 @default.
- W1985255191 hasConcept C2777083390 @default.
- W1985255191 hasConcept C2779329777 @default.
- W1985255191 hasConcept C2780221984 @default.
- W1985255191 hasConcept C44249647 @default.
- W1985255191 hasConcept C71924100 @default.
- W1985255191 hasConcept C72563966 @default.
- W1985255191 hasConcept C90924648 @default.
- W1985255191 hasConceptScore W1985255191C126322002 @default.
- W1985255191 hasConceptScore W1985255191C156957248 @default.
- W1985255191 hasConceptScore W1985255191C2776541429 @default.
- W1985255191 hasConceptScore W1985255191C2776886416 @default.
- W1985255191 hasConceptScore W1985255191C2777083390 @default.
- W1985255191 hasConceptScore W1985255191C2779329777 @default.
- W1985255191 hasConceptScore W1985255191C2780221984 @default.