Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985257314> ?p ?o ?g. }
- W1985257314 endingPage "249" @default.
- W1985257314 startingPage "240" @default.
- W1985257314 abstract "The goal of this study was to investigate whether glycosylphosphatidylinositol (GPI)-anchored 6 kDa early secreted antigenic target (ESAT-6) and IL-21-producing B16F10/ESAT-6-GPI-IL-21 viable vaccine would induce antitumor efficacy. Mice were immunized with B16F10/ESAT-6-GPI-IL-21 vaccine and challenged by B16F10 cells 2 weeks later. Antitumor efficacy and mechanisms of the vaccine were analyzed. Vaccination with the viable B16F10/ESAT-6-GPI-IL-21 vaccine resulted in an increase of IFN-γ level and the CD8(+)CTL cytotoxicity, a decrease in TGF-β generation and increase in the expression of miR-200c that serves as melanoma suppressor by directly targeting zinc-finger E-box binding homeobox 1 to inhibit epithelial-mesenchymal transition and block tumor metastasis. The vaccine significantly inhibited the melanoma growth, reduced the lung melanoma nodules, and prolonged the mouse survival compared with the controls. These findings highlighted IL-21 as an immune adjuvant in an engineered viable tumor vaccine to reinforce heterogenetic antigen ESAT-6 immune tolerance break to induce powerful antitumor efficacy in mice." @default.
- W1985257314 created "2016-06-24" @default.
- W1985257314 creator A5000571244 @default.
- W1985257314 creator A5005365404 @default.
- W1985257314 creator A5022467764 @default.
- W1985257314 creator A5037677450 @default.
- W1985257314 creator A5063945120 @default.
- W1985257314 creator A5065009308 @default.
- W1985257314 creator A5074339191 @default.
- W1985257314 creator A5074894656 @default.
- W1985257314 creator A5080606995 @default.
- W1985257314 date "2012-04-05" @default.
- W1985257314 modified "2023-09-25" @default.
- W1985257314 title "Antitumor efficacy of viable tumor vaccine modified by heterogenetic ESAT-6 antigen and cytokine IL-21 in melanomatous mouse" @default.
- W1985257314 cites W1605479195 @default.
- W1985257314 cites W1922507831 @default.
- W1985257314 cites W1966489816 @default.
- W1985257314 cites W1977473514 @default.
- W1985257314 cites W1981440982 @default.
- W1985257314 cites W1985241042 @default.
- W1985257314 cites W1994111355 @default.
- W1985257314 cites W2001758437 @default.
- W1985257314 cites W2023774776 @default.
- W1985257314 cites W2028525364 @default.
- W1985257314 cites W2035340171 @default.
- W1985257314 cites W2045927984 @default.
- W1985257314 cites W2046917463 @default.
- W1985257314 cites W2049541654 @default.
- W1985257314 cites W2052664182 @default.
- W1985257314 cites W2064581203 @default.
- W1985257314 cites W2066166771 @default.
- W1985257314 cites W2068368560 @default.
- W1985257314 cites W2069428724 @default.
- W1985257314 cites W2074861878 @default.
- W1985257314 cites W2099439420 @default.
- W1985257314 cites W2101139369 @default.
- W1985257314 cites W2103018035 @default.
- W1985257314 cites W2112666597 @default.
- W1985257314 cites W2112978304 @default.
- W1985257314 cites W2115095574 @default.
- W1985257314 cites W2151602943 @default.
- W1985257314 cites W2155131748 @default.
- W1985257314 cites W2163828646 @default.
- W1985257314 cites W2165047752 @default.
- W1985257314 cites W2167016095 @default.
- W1985257314 cites W2317703908 @default.
- W1985257314 doi "https://doi.org/10.1007/s12026-012-8332-4" @default.
- W1985257314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22477528" @default.
- W1985257314 hasPublicationYear "2012" @default.
- W1985257314 type Work @default.
- W1985257314 sameAs 1985257314 @default.
- W1985257314 citedByCount "25" @default.
- W1985257314 countsByYear W19852573142013 @default.
- W1985257314 countsByYear W19852573142014 @default.
- W1985257314 countsByYear W19852573142015 @default.
- W1985257314 countsByYear W19852573142016 @default.
- W1985257314 countsByYear W19852573142017 @default.
- W1985257314 countsByYear W19852573142020 @default.
- W1985257314 countsByYear W19852573142021 @default.
- W1985257314 countsByYear W19852573142022 @default.
- W1985257314 countsByYear W19852573142023 @default.
- W1985257314 crossrefType "journal-article" @default.
- W1985257314 hasAuthorship W1985257314A5000571244 @default.
- W1985257314 hasAuthorship W1985257314A5005365404 @default.
- W1985257314 hasAuthorship W1985257314A5022467764 @default.
- W1985257314 hasAuthorship W1985257314A5037677450 @default.
- W1985257314 hasAuthorship W1985257314A5063945120 @default.
- W1985257314 hasAuthorship W1985257314A5065009308 @default.
- W1985257314 hasAuthorship W1985257314A5074339191 @default.
- W1985257314 hasAuthorship W1985257314A5074894656 @default.
- W1985257314 hasAuthorship W1985257314A5080606995 @default.
- W1985257314 hasBestOaLocation W19852573141 @default.
- W1985257314 hasConcept C142724271 @default.
- W1985257314 hasConcept C147483822 @default.
- W1985257314 hasConcept C147969180 @default.
- W1985257314 hasConcept C167672396 @default.
- W1985257314 hasConcept C203014093 @default.
- W1985257314 hasConcept C22070199 @default.
- W1985257314 hasConcept C2777701055 @default.
- W1985257314 hasConcept C2777863537 @default.
- W1985257314 hasConcept C2777975735 @default.
- W1985257314 hasConcept C2778235839 @default.
- W1985257314 hasConcept C2778378633 @default.
- W1985257314 hasConcept C2778690821 @default.
- W1985257314 hasConcept C2781064340 @default.
- W1985257314 hasConcept C2781069245 @default.
- W1985257314 hasConcept C2911179620 @default.
- W1985257314 hasConcept C502942594 @default.
- W1985257314 hasConcept C71924100 @default.
- W1985257314 hasConcept C86803240 @default.
- W1985257314 hasConcept C8891405 @default.
- W1985257314 hasConceptScore W1985257314C142724271 @default.
- W1985257314 hasConceptScore W1985257314C147483822 @default.
- W1985257314 hasConceptScore W1985257314C147969180 @default.
- W1985257314 hasConceptScore W1985257314C167672396 @default.
- W1985257314 hasConceptScore W1985257314C203014093 @default.
- W1985257314 hasConceptScore W1985257314C22070199 @default.
- W1985257314 hasConceptScore W1985257314C2777701055 @default.