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• W1985260087 abstract "The nuclear genome of the human malaria parasite Plasmodium falciparum encodes a homolog of the bacterial HU protein (PfHU). In this study, we characterised PfHU's physiological function. PfHU, which is targeted exclusively to the parasite's plastid, bound its natural target – the plastid DNA – sequence‐independently and complemented lack of HU in Escherichia coli . The HU gene could not be knocked‐out from the genome of Plasmodium berghei , implying that HU is important for the parasite's survival. As the human cell lacks the HU homolog, PfHU is a potential target for drugs to control malaria." @default.
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• W1985260087 date "2009-04-07" @default.
• W1985260087 modified "2023-10-15" @default.
• W1985260087 title "The<i>Plasmodium</i>HU homolog, which binds the plastid DNA sequence-independent manner, is essential for the parasite's survival" @default.
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• W1985260087 doi "https://doi.org/10.1016/j.febslet.2009.03.071" @default.
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