FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985261796> ?p ?o ?g. }

• W1985261796 endingPage "3413" @default.
• W1985261796 startingPage "3408" @default.
• W1985261796 abstract "ABSTRACT This randomized, double-blind, multicenter trial compared the efficacy and safety of linezolid, an oxazolidinone, with those of oxacillin-dicloxacillin in patients with complicated skin and soft tissue infections. A total of 826 hospitalized adult patients were randomized to receive linezolid (600 mg intravenously [i.v.]) every 12 h or oxacillin (2 g i.v.) every 6 h; following sufficient clinical improvement, patients were switched to the respective oral agents (linezolid [600 mg orally] every 12 h or dicloxacillin [500 mg orally] every 6 hours). Primary efficacy variables were clinical cure rates in both the intent-to-treat (ITT) population and clinically evaluable (CE) patients and microbiological success rate in microbiologically evaluable (ME) patients. Safety and tolerability were evaluated in the ITT population. Demographics and baseline characteristics were similar across treatment groups in the 819 ITT patients. In the ITT population, the clinical cure rates were 69.8 and 64.9% in the linezolid and oxacillin-dicloxacillin groups, respectively ( P = 0.141; 95% confidence interval −1.58 to 11.25). In 298 CE linezolid-treated patients, the clinical cure rate was 88.6%, compared with a cure rate of 85.8% in 302 CE patients who received oxacillin-dicloxacillin. In 143 ME linezolid-treated patients, the microbiological success rate was 88.1%, compared with a success rate of 86.1% in 151 ME patients who received oxacillin-dicloxacillin. Both agents were well tolerated; most adverse events were of mild-to-moderate intensity. No serious drug-related adverse events were reported in the linezolid group. These data support the use of linezolid for the treatment of adults with complicated skin and soft tissue infections." @default.
• W1985261796 created "2016-06-24" @default.
• W1985261796 creator A5018464543 @default.
• W1985261796 creator A5023674450 @default.
• W1985261796 creator A5057714792 @default.
• W1985261796 creator A5062594893 @default.
• W1985261796 creator A5066950979 @default.
• W1985261796 creator A5081793602 @default.
• W1985261796 creator A5087580457 @default.
• W1985261796 date "2000-12-01" @default.
• W1985261796 modified "2023-10-16" @default.
• W1985261796 title "Randomized Comparison of Linezolid (PNU-100766) versus Oxacillin-Dicloxacillin for Treatment of Complicated Skin and Soft Tissue Infections" @default.
• W1985261796 cites W1596505006 @default.
• W1985261796 cites W1627830838 @default.
• W1985261796 cites W1859276716 @default.
• W1985261796 cites W1964119169 @default.
• W1985261796 cites W1974315333 @default.
• W1985261796 cites W1979770903 @default.
• W1985261796 cites W2008303960 @default.
• W1985261796 cites W2040000199 @default.
• W1985261796 cites W2053115956 @default.
• W1985261796 cites W2054350590 @default.
• W1985261796 cites W2082816719 @default.
• W1985261796 cites W2117173742 @default.
• W1985261796 cites W2130079498 @default.
• W1985261796 cites W2134137013 @default.
• W1985261796 cites W2139316387 @default.
• W1985261796 cites W2140777443 @default.
• W1985261796 cites W2143541324 @default.
• W1985261796 cites W2149375508 @default.
• W1985261796 cites W2151859311 @default.
• W1985261796 cites W2155003800 @default.
• W1985261796 cites W2162500075 @default.
• W1985261796 cites W2330420020 @default.
• W1985261796 cites W4296720031 @default.
• W1985261796 doi "https://doi.org/10.1128/aac.44.12.3408-3413.2000" @default.
• W1985261796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/90213" @default.
• W1985261796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11083648" @default.
• W1985261796 hasPublicationYear "2000" @default.
• W1985261796 type Work @default.
• W1985261796 sameAs 1985261796 @default.
• W1985261796 citedByCount "228" @default.
• W1985261796 countsByYear W19852617962012 @default.
• W1985261796 countsByYear W19852617962013 @default.
• W1985261796 countsByYear W19852617962014 @default.
• W1985261796 countsByYear W19852617962015 @default.
• W1985261796 countsByYear W19852617962016 @default.
• W1985261796 countsByYear W19852617962017 @default.
• W1985261796 countsByYear W19852617962018 @default.
• W1985261796 countsByYear W19852617962019 @default.
• W1985261796 countsByYear W19852617962020 @default.
• W1985261796 countsByYear W19852617962021 @default.
• W1985261796 countsByYear W19852617962022 @default.
• W1985261796 countsByYear W19852617962023 @default.
• W1985261796 crossrefType "journal-article" @default.
• W1985261796 hasAuthorship W1985261796A5018464543 @default.
• W1985261796 hasAuthorship W1985261796A5023674450 @default.
• W1985261796 hasAuthorship W1985261796A5057714792 @default.
• W1985261796 hasAuthorship W1985261796A5062594893 @default.
• W1985261796 hasAuthorship W1985261796A5066950979 @default.
• W1985261796 hasAuthorship W1985261796A5081793602 @default.
• W1985261796 hasAuthorship W1985261796A5087580457 @default.
• W1985261796 hasBestOaLocation W19852617961 @default.
• W1985261796 hasConcept C126322002 @default.
• W1985261796 hasConcept C141071460 @default.
• W1985261796 hasConcept C168563851 @default.
• W1985261796 hasConcept C174802600 @default.
• W1985261796 hasConcept C197934379 @default.
• W1985261796 hasConcept C2776141307 @default.
• W1985261796 hasConcept C2778375690 @default.
• W1985261796 hasConcept C2778980435 @default.
• W1985261796 hasConcept C2779489039 @default.
• W1985261796 hasConcept C2781414143 @default.
• W1985261796 hasConcept C2908647359 @default.
• W1985261796 hasConcept C3019249092 @default.
• W1985261796 hasConcept C501593827 @default.
• W1985261796 hasConcept C523546767 @default.
• W1985261796 hasConcept C54355233 @default.
• W1985261796 hasConcept C71924100 @default.
• W1985261796 hasConcept C86803240 @default.
• W1985261796 hasConcept C89423630 @default.
• W1985261796 hasConcept C99454951 @default.
• W1985261796 hasConceptScore W1985261796C126322002 @default.
• W1985261796 hasConceptScore W1985261796C141071460 @default.
• W1985261796 hasConceptScore W1985261796C168563851 @default.
• W1985261796 hasConceptScore W1985261796C174802600 @default.
• W1985261796 hasConceptScore W1985261796C197934379 @default.
• W1985261796 hasConceptScore W1985261796C2776141307 @default.
• W1985261796 hasConceptScore W1985261796C2778375690 @default.
• W1985261796 hasConceptScore W1985261796C2778980435 @default.
• W1985261796 hasConceptScore W1985261796C2779489039 @default.
• W1985261796 hasConceptScore W1985261796C2781414143 @default.
• W1985261796 hasConceptScore W1985261796C2908647359 @default.
• W1985261796 hasConceptScore W1985261796C3019249092 @default.
• W1985261796 hasConceptScore W1985261796C501593827 @default.
• W1985261796 hasConceptScore W1985261796C523546767 @default.
• W1985261796 hasConceptScore W1985261796C54355233 @default.
• W1985261796 hasConceptScore W1985261796C71924100 @default.

• next