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• W1985266827 endingPage "R535" @default.
• W1985266827 startingPage "R526" @default.
• W1985266827 abstract "beta-Adrenoceptors (beta-ARs) are seven-transmembrane domain, G protein-coupled receptors that transduce the cellular effects of epinephrine and norepinephrine and play a pivotal role in the vertebrate stress response. This study reports the cloning and characterization of two previously unreported beta-ARs from the rainbow trout (Oncorhynchus mykiss). Phylogenetic analysis of amino acid sequences indicates that both beta-ARs are homologs of the mammalian beta3-AR. Analysis of tissue expression patterns indicates that one of these trout beta3-adrenoceptors (beta3a-AR) is highly expressed in gill and heart, whereas the second (beta3b-AR) is highly expressed by red blood cells (RBC). Expression of the beta3b-AR in the RBC coupled with the finding of a single category of beta-AR binding sites on RBC membranes provides strong evidence for the control of the trout RBC beta-AR Na+/H+ exchanger (beta-NHE) activity by signaling through this beta3b-subtype and not through a beta1-subtype as previously proposed. The RBC-specific trout beta3b-AR exhibits binding characteristics that distinguish this receptor from each of the three pharmacologically defined categories of mammalian beta-ARs (beta1-, beta2-, and beta3-AR). This study is the first to report the presence of a beta3-AR subtype in a fish species, and the proposal that the beta3b-AR controls RBC beta-NHE activity represents a novel role for the beta3-AR subtype in vertebrates." @default.
• W1985266827 created "2016-06-24" @default.
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• W1985266827 date "2003-09-01" @default.
• W1985266827 modified "2023-10-18" @default.
• W1985266827 title "Activity of the unique β-adrenergic Na⁺/H⁺exchanger in trout erythrocytes is controlled by a novel β₃-AR subtype" @default.
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• W1985266827 doi "https://doi.org/10.1152/ajpregu.00146.2003" @default.
• W1985266827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12775554" @default.
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