FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985268469> ?p ?o ?g. }

• W1985268469 endingPage "1363" @default.
• W1985268469 startingPage "1355" @default.
• W1985268469 abstract "Pancreatic cancer is the most lethal of all solid tumors partially because of its chemoresistance. Although gemcitabine is widely used as a first selected agent for the treatment of this disease despite low response rate, molecular mechanisms of gemcitabine resistance in pancreatic cancer still remain obscure. The aim of this study is to elucidate the mechanisms of gemcitabine resistance. The 81-fold gemcitabine resistant variant MiaPaCa2-RG was selected from pancreatic cancer cell line MiaPaCa2. By microarray analysis between MiaPaCa2 and MiaPaCa2-RG, 43 genes (0.04%) were altered expression of more than 2-fold. The most upregulated gene in MiaPaCa2-RG was ribonucleotide reductase M1 subunit (RRM1) with 4.5-fold up-regulation. Transfection with RRM1-specific RNAi suppressed more than 90% of RRM1 mRNA and protein expression. After RRM1-specific RNAi transfection, gemcitabine chemoresistance of MiaPaCa2-RG was reduced to the same level of MiaPaCa2. The 18 recurrent pancreatic cancer patients treated by gemcitabine were divided into 2 groups by RRM1 levels. There was a significant association between gemcitabine response and RRM1 expression (p = 0.018). Patients with high RRM1 levels had poor survival after gemcitabine treatment than those with low RRM1 levels (p = 0.016). RRM1 should be a key molecule in gemcitabine resistance in human pancreatic cancer through both in vitro and clinical models. RRM1 may have the potential as predictor and modulator of gemcitabine treatment." @default.
• W1985268469 created "2016-06-24" @default.
• W1985268469 creator A5001408222 @default.
• W1985268469 creator A5013129966 @default.
• W1985268469 creator A5014204252 @default.
• W1985268469 creator A5020681554 @default.
• W1985268469 creator A5023602886 @default.
• W1985268469 creator A5027125823 @default.
• W1985268469 creator A5036451745 @default.
• W1985268469 creator A5037320870 @default.
• W1985268469 creator A5038014472 @default.
• W1985268469 creator A5038916352 @default.
• W1985268469 creator A5040965828 @default.
• W1985268469 creator A5051159437 @default.
• W1985268469 creator A5059872605 @default.
• W1985268469 creator A5061233614 @default.
• W1985268469 creator A5079989633 @default.
• W1985268469 creator A5080581587 @default.
• W1985268469 date "2007-01-01" @default.
• W1985268469 modified "2023-09-26" @default.
• W1985268469 title "Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer" @default.
• W1985268469 cites W1504844653 @default.
• W1985268469 cites W1583339960 @default.
• W1985268469 cites W1584870064 @default.
• W1985268469 cites W1910707858 @default.
• W1985268469 cites W1931508686 @default.
• W1985268469 cites W1994411692 @default.
• W1985268469 cites W2000465781 @default.
• W1985268469 cites W2009486080 @default.
• W1985268469 cites W2010281770 @default.
• W1985268469 cites W2018961890 @default.
• W1985268469 cites W2022237067 @default.
• W1985268469 cites W2031807994 @default.
• W1985268469 cites W2047877548 @default.
• W1985268469 cites W2049894527 @default.
• W1985268469 cites W2074459357 @default.
• W1985268469 cites W2078757355 @default.
• W1985268469 cites W2090137771 @default.
• W1985268469 cites W2095287544 @default.
• W1985268469 cites W2097642908 @default.
• W1985268469 cites W2107565528 @default.
• W1985268469 cites W2114918609 @default.
• W1985268469 cites W2117844134 @default.
• W1985268469 cites W2129489850 @default.
• W1985268469 cites W2139248078 @default.
• W1985268469 cites W2142694173 @default.
• W1985268469 cites W2159441446 @default.
• W1985268469 cites W2161769699 @default.
• W1985268469 cites W2164529446 @default.
• W1985268469 cites W2168070336 @default.
• W1985268469 cites W2171556157 @default.
• W1985268469 cites W2419243510 @default.
• W1985268469 cites W4247785462 @default.
• W1985268469 cites W4248412843 @default.
• W1985268469 doi "https://doi.org/10.1002/ijc.22390" @default.
• W1985268469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17131328" @default.
• W1985268469 hasPublicationYear "2007" @default.
• W1985268469 type Work @default.
• W1985268469 sameAs 1985268469 @default.
• W1985268469 citedByCount "175" @default.
• W1985268469 countsByYear W19852684692012 @default.
• W1985268469 countsByYear W19852684692013 @default.
• W1985268469 countsByYear W19852684692014 @default.
• W1985268469 countsByYear W19852684692015 @default.
• W1985268469 countsByYear W19852684692016 @default.
• W1985268469 countsByYear W19852684692017 @default.
• W1985268469 countsByYear W19852684692018 @default.
• W1985268469 countsByYear W19852684692019 @default.
• W1985268469 countsByYear W19852684692020 @default.
• W1985268469 countsByYear W19852684692021 @default.
• W1985268469 countsByYear W19852684692022 @default.
• W1985268469 countsByYear W19852684692023 @default.
• W1985268469 crossrefType "journal-article" @default.
• W1985268469 hasAuthorship W1985268469A5001408222 @default.
• W1985268469 hasAuthorship W1985268469A5013129966 @default.
• W1985268469 hasAuthorship W1985268469A5014204252 @default.
• W1985268469 hasAuthorship W1985268469A5020681554 @default.
• W1985268469 hasAuthorship W1985268469A5023602886 @default.
• W1985268469 hasAuthorship W1985268469A5027125823 @default.
• W1985268469 hasAuthorship W1985268469A5036451745 @default.
• W1985268469 hasAuthorship W1985268469A5037320870 @default.
• W1985268469 hasAuthorship W1985268469A5038014472 @default.
• W1985268469 hasAuthorship W1985268469A5038916352 @default.
• W1985268469 hasAuthorship W1985268469A5040965828 @default.
• W1985268469 hasAuthorship W1985268469A5051159437 @default.
• W1985268469 hasAuthorship W1985268469A5059872605 @default.
• W1985268469 hasAuthorship W1985268469A5061233614 @default.
• W1985268469 hasAuthorship W1985268469A5079989633 @default.
• W1985268469 hasAuthorship W1985268469A5080581587 @default.
• W1985268469 hasBestOaLocation W19852684691 @default.
• W1985268469 hasConcept C104292427 @default.
• W1985268469 hasConcept C104317684 @default.
• W1985268469 hasConcept C121608353 @default.
• W1985268469 hasConcept C126322002 @default.
• W1985268469 hasConcept C143998085 @default.
• W1985268469 hasConcept C2780210213 @default.
• W1985268469 hasConcept C2780258809 @default.
• W1985268469 hasConcept C4710235 @default.

• next