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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985288001> ?p ?o ?g. }

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• W1985288001 abstract "We describe here a novel 4-amino-2-cyanopyrimidine scaffold for nonpeptidomimetic cathepsin S selective inhibitors. Some of the synthesized compounds have sub-nanomolar potency and high selectivity toward cathepsin S along with promising pharmacokinetic and physicochemical properties. The key structural features of the inhibitors consist of a combination of a spiro[2.5]oct-6-ylmethylamine P2 group at the 4-position, a small or polar P3 group at the 5-position and/or a polar group at the 6-position of the pyrimidine." @default.
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• W1985288001 date "2008-08-01" @default.
• W1985288001 modified "2023-09-26" @default.
• W1985288001 title "4-Amino-2-cyanopyrimidines: Novel scaffold for nonpeptidic cathepsin S inhibitors" @default.
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• W1985288001 doi "https://doi.org/10.1016/j.bmcl.2008.07.011" @default.
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