FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985292847> ?p ?o ?g. }

• W1985292847 endingPage "117" @default.
• W1985292847 startingPage "111" @default.
• W1985292847 abstract "Background Liquid chromatography linked to tandem mass spectrometry (LC/MS/MS) provides the ability to identify a range of benzodiazepines in accordance with European Union criteria and is an attractive method for the confirmation of benzodiazepines following immunoassay screening. Methods An LC/MS/MS method to detect and quantitate the six most common benzodiazepines/metabolites (diazepam, nitrazepam, nordiazepam, oxazepam, temazepam and 7-aminonitrazepam) was developed together with a qualitative screening method for a further 11 benzodiazepines/metabolites. These methods were used for confirmation of 250 urine samples submitted for routine drug screening by immunoassay for benzodiazepines (100 samples positive for a benzodiazepine, assay cut-off >200 μsg/L). Results The lower limits of detection and quantitation were less than 2.5 and 5 μg/L for the six most common benzodiazepines. Recoveries ranged between 97% and 102% and calibration curves were linear to at least 4000 μg/L ( r = 0.99). Intra and inter-assay imprecision were <10% ( n = 10) and <20% ( n = 15), respectively. Confirmation of benzodiazepines using LC/MS/MS was achieved for 89% of the immunoassay-positive urine samples. Of the immunoassay-negative urine samples, 31% of these demonstrated a benzodiazepine using LC/MS/MS. Conclusion The validated LC/MS/MS method developed is effective for the confirmation of immunoassay screening results for benzodiazepines. The lower limit of detection and assay specificity offers a longer window of detection and more detailed clinical information compared with immunoassay screening." @default.
• W1985292847 created "2016-06-24" @default.
• W1985292847 creator A5029538789 @default.
• W1985292847 creator A5085704802 @default.
• W1985292847 date "2009-12-07" @default.
• W1985292847 modified "2023-10-14" @default.
• W1985292847 title "Measurement of benzodiazepines in urine by liquid chromatography-tandem mass spectrometry: confirmation of samples screened by immunoassay" @default.
• W1985292847 cites W1972311592 @default.
• W1985292847 cites W1980716994 @default.
• W1985292847 cites W1986620546 @default.
• W1985292847 cites W2011407833 @default.
• W1985292847 cites W2033923937 @default.
• W1985292847 cites W2065083077 @default.
• W1985292847 cites W2101665151 @default.
• W1985292847 cites W2117560622 @default.
• W1985292847 cites W2119306278 @default.
• W1985292847 cites W2136737356 @default.
• W1985292847 cites W2138546671 @default.
• W1985292847 cites W2140695271 @default.
• W1985292847 cites W2163402540 @default.
• W1985292847 cites W2165355500 @default.
• W1985292847 cites W2165862422 @default.
• W1985292847 cites W2166485872 @default.
• W1985292847 cites W2169560189 @default.
• W1985292847 cites W2188058039 @default.
• W1985292847 cites W2228247746 @default.
• W1985292847 cites W2262123630 @default.
• W1985292847 cites W2325470784 @default.
• W1985292847 cites W2332901890 @default.
• W1985292847 cites W4232585809 @default.
• W1985292847 doi "https://doi.org/10.1258/acb.2009.009172" @default.
• W1985292847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19969595" @default.
• W1985292847 hasPublicationYear "2009" @default.
• W1985292847 type Work @default.
• W1985292847 sameAs 1985292847 @default.
• W1985292847 citedByCount "24" @default.
• W1985292847 countsByYear W19852928472012 @default.
• W1985292847 countsByYear W19852928472013 @default.
• W1985292847 countsByYear W19852928472015 @default.
• W1985292847 countsByYear W19852928472016 @default.
• W1985292847 countsByYear W19852928472017 @default.
• W1985292847 countsByYear W19852928472018 @default.
• W1985292847 countsByYear W19852928472021 @default.
• W1985292847 countsByYear W19852928472022 @default.
• W1985292847 countsByYear W19852928472023 @default.
• W1985292847 crossrefType "journal-article" @default.
• W1985292847 hasAuthorship W1985292847A5029538789 @default.
• W1985292847 hasAuthorship W1985292847A5085704802 @default.
• W1985292847 hasConcept C119128265 @default.
• W1985292847 hasConcept C159654299 @default.
• W1985292847 hasConcept C162356407 @default.
• W1985292847 hasConcept C170493617 @default.
• W1985292847 hasConcept C185592680 @default.
• W1985292847 hasConcept C203014093 @default.
• W1985292847 hasConcept C2776175493 @default.
• W1985292847 hasConcept C2776615572 @default.
• W1985292847 hasConcept C2777207853 @default.
• W1985292847 hasConcept C2778173252 @default.
• W1985292847 hasConcept C2780026642 @default.
• W1985292847 hasConcept C2780420688 @default.
• W1985292847 hasConcept C2781006864 @default.
• W1985292847 hasConcept C31827203 @default.
• W1985292847 hasConcept C43617362 @default.
• W1985292847 hasConcept C55493867 @default.
• W1985292847 hasConcept C64489805 @default.
• W1985292847 hasConcept C71924100 @default.
• W1985292847 hasConcept C98274493 @default.
• W1985292847 hasConceptScore W1985292847C119128265 @default.
• W1985292847 hasConceptScore W1985292847C159654299 @default.
• W1985292847 hasConceptScore W1985292847C162356407 @default.
• W1985292847 hasConceptScore W1985292847C170493617 @default.
• W1985292847 hasConceptScore W1985292847C185592680 @default.
• W1985292847 hasConceptScore W1985292847C203014093 @default.
• W1985292847 hasConceptScore W1985292847C2776175493 @default.
• W1985292847 hasConceptScore W1985292847C2776615572 @default.
• W1985292847 hasConceptScore W1985292847C2777207853 @default.
• W1985292847 hasConceptScore W1985292847C2778173252 @default.
• W1985292847 hasConceptScore W1985292847C2780026642 @default.
• W1985292847 hasConceptScore W1985292847C2780420688 @default.
• W1985292847 hasConceptScore W1985292847C2781006864 @default.
• W1985292847 hasConceptScore W1985292847C31827203 @default.
• W1985292847 hasConceptScore W1985292847C43617362 @default.
• W1985292847 hasConceptScore W1985292847C55493867 @default.
• W1985292847 hasConceptScore W1985292847C64489805 @default.
• W1985292847 hasConceptScore W1985292847C71924100 @default.
• W1985292847 hasConceptScore W1985292847C98274493 @default.
• W1985292847 hasIssue "2" @default.
• W1985292847 hasLocation W19852928471 @default.
• W1985292847 hasLocation W19852928472 @default.
• W1985292847 hasOpenAccess W1985292847 @default.
• W1985292847 hasPrimaryLocation W19852928471 @default.
• W1985292847 hasRelatedWork W1973261120 @default.
• W1985292847 hasRelatedWork W1985292847 @default.
• W1985292847 hasRelatedWork W1987657867 @default.
• W1985292847 hasRelatedWork W2038296003 @default.
• W1985292847 hasRelatedWork W2071434648 @default.
• W1985292847 hasRelatedWork W2129035781 @default.
• W1985292847 hasRelatedWork W2164920460 @default.

• next