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• W1985293610 abstract "The appearance of ion channels was induced in phospholipid bilayers by acidification of the bulk solution on one side of the bilayer. by addition of HCl. acetic acid or by hydrolytic production of protons using purified acetylcholinesierase. Further acidification below an apparent critical pH range led to restoration of a low conductance state similar to that seen at neutral pH. Such experiments were performed with a heterogeneous soybean lecithin extract, with homogeneous synthetic di-phytanoylphosphatidylcholine, and with a mixture of cholesterol and synthetic dioleoylphosphatdylcholine. It is proposed that the physical mechanism for this phenomenon involves fluctuations of lipid order induced by fluctuations in protnation of phospholipid head groups within a critical pH range; these, in turn, create conductive defect in the two-dimensional lattice of the lipid bilayer." @default.
• W1985293610 created "2016-06-24" @default.
• W1985293610 creator A5025933576 @default.
• W1985293610 creator A5053061093 @default.
• W1985293610 date "1983-09-01" @default.
• W1985293610 modified "2023-09-27" @default.
• W1985293610 title "The induction by protons of ion channels through lipid bilayer membranes" @default.
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• W1985293610 doi "https://doi.org/10.1016/0301-4622(83)85002-9" @default.
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