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- W1985295306 abstract "CD8α+ dendritic cells (DCs) prime cytotoxic T lymphocytes during viral infections and produce interleukin-12 in response to pathogens. Although the loss of CD8α+ DCs in Batf3−/− mice increases their susceptibility to several pathogens, we observed that Batf3−/− mice exhibited enhanced resistance to the intracellular bacterium Listeria monocytogenes. In wild-type mice, Listeria organisms, initially located in the splenic marginal zone, migrated to the periarteriolar lymphoid sheath (PALS) where they grew exponentially and induced widespread lymphocyte apoptosis. In Batf3−/− mice, however, Listeria organisms remain trapped in the marginal zone, failed to traffic into the PALS, and were rapidly cleared by phagocytes. In addition, Batf3−/− mice, which lacked the normal population of hepatic CD103+ peripheral DCs, also showed protection from liver infection. These results suggest that Batf3-dependent CD8α+ and CD103+ DCs provide initial cellular entry points within the reticuloendothelial system by which Listeria establishes productive infection." @default.
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- W1985295306 date "2011-08-01" @default.
- W1985295306 modified "2023-10-18" @default.
- W1985295306 title "CD8α+ Dendritic Cells Are an Obligate Cellular Entry Point for Productive Infection by Listeria monocytogenes" @default.
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- W1985295306 doi "https://doi.org/10.1016/j.immuni.2011.06.012" @default.
- W1985295306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3172670" @default.
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