FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985302513> ?p ?o ?g. }

• W1985302513 endingPage "62" @default.
• W1985302513 startingPage "51" @default.
• W1985302513 abstract "This study examines whether retinoids are essential in the reproduction of zebrafish. Using RT-PCR, it was shown that the ovaries and testes express enzymes that synthesize and metabolize the hormone retinoic acid (RA) (raldh2 and cyp26a, respectively), and RA receptors (raraa, rarga, rxrba, rxrbb, rxrga but not rxrab). Three new isoforms of rxrba were also observed in a variety of tissues. In other experiments, zebrafish were exposed for 11 d to diethylaminobenzaldehyde (DEAB), an inhibitor of RA synthesis, or fed a retinoid deficient diet for 130 d in order to evaluate the functional requirements of retinoids in reproduction. DEAB altered cyp26a transcript numbers in the gonads, suggesting an impact on RA, and decreased the number of spawned eggs by 95%. The retinoid deficient diet decreased whole body retinoids (retinol and retinal) by 68% in females and 33% in males. Females fed the retinoid deficient diet also produced 73% fewer eggs that contained 78% less retinal than controls. Fertilization rates were not affected. These studies have shown that the RA receptors are expressed in zebrafish gonads, and RA is required for the spawning of eggs. Dietary retinoid content influences reproduction, while retinyl ester storage levels appear to be of little significance. Females were more susceptible to retinoid perturbation than males, likely due to the cost of retinal deposition in the eggs. Overall, these studies have shown retinoids play a fundamental role in the reproduction of zebrafish, and the lack of retinyl ester stores in controls that successfully spawned illustrates that we have only a limited understanding of the retinoid physiology and requirements of fish." @default.
• W1985302513 created "2016-06-24" @default.
• W1985302513 creator A5010140238 @default.
• W1985302513 creator A5014771273 @default.
• W1985302513 creator A5027004646 @default.
• W1985302513 creator A5071655116 @default.
• W1985302513 date "2008-03-01" @default.
• W1985302513 modified "2023-10-15" @default.
• W1985302513 title "Retinoid requirements in the reproduction of zebrafish" @default.
• W1985302513 cites W1862368760 @default.
• W1985302513 cites W1973726394 @default.
• W1985302513 cites W1980976351 @default.
• W1985302513 cites W1981261718 @default.
• W1985302513 cites W1988750841 @default.
• W1985302513 cites W1992151395 @default.
• W1985302513 cites W1999332593 @default.
• W1985302513 cites W2000502515 @default.
• W1985302513 cites W2003701112 @default.
• W1985302513 cites W2008208329 @default.
• W1985302513 cites W2018759592 @default.
• W1985302513 cites W2019619778 @default.
• W1985302513 cites W2021047790 @default.
• W1985302513 cites W2027053207 @default.
• W1985302513 cites W2039122086 @default.
• W1985302513 cites W2041506809 @default.
• W1985302513 cites W2052568266 @default.
• W1985302513 cites W2055431484 @default.
• W1985302513 cites W2063071321 @default.
• W1985302513 cites W2065092823 @default.
• W1985302513 cites W2067256177 @default.
• W1985302513 cites W2068417079 @default.
• W1985302513 cites W2072262579 @default.
• W1985302513 cites W2089145320 @default.
• W1985302513 cites W2092406654 @default.
• W1985302513 cites W2093331522 @default.
• W1985302513 cites W2099841716 @default.
• W1985302513 cites W2100326385 @default.
• W1985302513 cites W2106521994 @default.
• W1985302513 cites W2111076275 @default.
• W1985302513 cites W2112742649 @default.
• W1985302513 cites W2118323778 @default.
• W1985302513 cites W2118419290 @default.
• W1985302513 cites W2118812285 @default.
• W1985302513 cites W2120657236 @default.
• W1985302513 cites W2121124656 @default.
• W1985302513 cites W2126713523 @default.
• W1985302513 cites W2127394974 @default.
• W1985302513 cites W2137085552 @default.
• W1985302513 cites W2142877387 @default.
• W1985302513 cites W2160269142 @default.
• W1985302513 cites W2166894429 @default.
• W1985302513 cites W2172184136 @default.
• W1985302513 cites W2287221549 @default.
• W1985302513 cites W4234422562 @default.
• W1985302513 cites W4294216491 @default.
• W1985302513 cites W4300350822 @default.
• W1985302513 doi "https://doi.org/10.1016/j.ygcen.2007.11.008" @default.
• W1985302513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18158153" @default.
• W1985302513 hasPublicationYear "2008" @default.
• W1985302513 type Work @default.
• W1985302513 sameAs 1985302513 @default.
• W1985302513 citedByCount "55" @default.
• W1985302513 countsByYear W19853025132012 @default.
• W1985302513 countsByYear W19853025132013 @default.
• W1985302513 countsByYear W19853025132014 @default.
• W1985302513 countsByYear W19853025132015 @default.
• W1985302513 countsByYear W19853025132016 @default.
• W1985302513 countsByYear W19853025132017 @default.
• W1985302513 countsByYear W19853025132018 @default.
• W1985302513 countsByYear W19853025132019 @default.
• W1985302513 countsByYear W19853025132020 @default.
• W1985302513 countsByYear W19853025132021 @default.
• W1985302513 countsByYear W19853025132022 @default.
• W1985302513 countsByYear W19853025132023 @default.
• W1985302513 crossrefType "journal-article" @default.
• W1985302513 hasAuthorship W1985302513A5010140238 @default.
• W1985302513 hasAuthorship W1985302513A5014771273 @default.
• W1985302513 hasAuthorship W1985302513A5027004646 @default.
• W1985302513 hasAuthorship W1985302513A5071655116 @default.
• W1985302513 hasConcept C104317684 @default.
• W1985302513 hasConcept C126322002 @default.
• W1985302513 hasConcept C128821507 @default.
• W1985302513 hasConcept C134018914 @default.
• W1985302513 hasConcept C170493617 @default.
• W1985302513 hasConcept C2775954498 @default.
• W1985302513 hasConcept C2776878037 @default.
• W1985302513 hasConcept C2776940978 @default.
• W1985302513 hasConcept C2779573558 @default.
• W1985302513 hasConcept C2780827179 @default.
• W1985302513 hasConcept C2781121885 @default.
• W1985302513 hasConcept C54355233 @default.
• W1985302513 hasConcept C55493867 @default.
• W1985302513 hasConcept C59659247 @default.
• W1985302513 hasConcept C63932345 @default.
• W1985302513 hasConcept C68484354 @default.
• W1985302513 hasConcept C71315377 @default.
• W1985302513 hasConcept C71924100 @default.
• W1985302513 hasConcept C758759 @default.

• next