Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985303224> ?p ?o ?g. }
- W1985303224 endingPage "3864" @default.
- W1985303224 startingPage "3859" @default.
- W1985303224 abstract "Early steps for cardiac specification are problematic for the study of mammalian embryos, which has favored using pluripotent cells that recapitulate cardiac myogenesis. Furthermore, circuits governing cardiac specification have relevance to the application of ES cells and other cells for heart repair. In mouse teratocarcinoma cells, canonical Wnts that inhibit heart formation in avian or amphibian embryos and explants activate cardiogenesis, paradoxically. Here, we show that the Wnt/β-catenin pathway also is essential for cardiac myogenesis to occur in ES cells, acting at a gastrulation-like stage, mediating mesoderm formation and patterning (two prerequisites for cardiac myogenesis itself). Among genes associated temporally with this step was Sox17 , encoding an endodermal HMG-box transcription factor. Using lentiviral vectors for RNA interference in differentiating ES cells, an essential role for Sox17 was proven in cardiac muscle cell formation. Sox17 short-hairpin RNA suppresses cardiac myogenesis selectively, acting subsequent to mesoderm formation yet before induction of Mesp1 and Mesp2 , a pair of related basic helix–loop–helix transcription factors that together are indispensable for creating heart mesoderm. Sox17 short-hairpin RNA blocks cardiac myogenesis non-cell autonomously and impairs the induction of Hex, a homeodomain transcription factor that is known to be required for the production of endoderm-derived heart-inducing factors." @default.
- W1985303224 created "2016-06-24" @default.
- W1985303224 creator A5009263498 @default.
- W1985303224 creator A5012528142 @default.
- W1985303224 creator A5016781421 @default.
- W1985303224 creator A5024722455 @default.
- W1985303224 creator A5043760837 @default.
- W1985303224 creator A5051287989 @default.
- W1985303224 creator A5057184445 @default.
- W1985303224 creator A5066413760 @default.
- W1985303224 creator A5070434265 @default.
- W1985303224 date "2007-03-06" @default.
- W1985303224 modified "2023-10-16" @default.
- W1985303224 title "<i>Sox17</i> is essential for the specification of cardiac mesoderm in embryonic stem cells" @default.
- W1985303224 cites W1570007846 @default.
- W1985303224 cites W1925655957 @default.
- W1985303224 cites W1965419330 @default.
- W1985303224 cites W1970452404 @default.
- W1985303224 cites W1977376400 @default.
- W1985303224 cites W1982748372 @default.
- W1985303224 cites W1987079301 @default.
- W1985303224 cites W1990903306 @default.
- W1985303224 cites W1993932646 @default.
- W1985303224 cites W1999444936 @default.
- W1985303224 cites W2001356111 @default.
- W1985303224 cites W2015050458 @default.
- W1985303224 cites W2023002592 @default.
- W1985303224 cites W2038437697 @default.
- W1985303224 cites W2048177058 @default.
- W1985303224 cites W2053781137 @default.
- W1985303224 cites W2055808176 @default.
- W1985303224 cites W2065535087 @default.
- W1985303224 cites W2067916728 @default.
- W1985303224 cites W2075469935 @default.
- W1985303224 cites W2075598942 @default.
- W1985303224 cites W2079181843 @default.
- W1985303224 cites W2084109090 @default.
- W1985303224 cites W2086892504 @default.
- W1985303224 cites W2089426706 @default.
- W1985303224 cites W2092664596 @default.
- W1985303224 cites W2097276145 @default.
- W1985303224 cites W2099468525 @default.
- W1985303224 cites W2119284420 @default.
- W1985303224 cites W2122059700 @default.
- W1985303224 cites W2132556256 @default.
- W1985303224 cites W2133447907 @default.
- W1985303224 cites W2138053255 @default.
- W1985303224 cites W2141321748 @default.
- W1985303224 cites W2145295859 @default.
- W1985303224 cites W2145495388 @default.
- W1985303224 cites W2149660935 @default.
- W1985303224 cites W2153811819 @default.
- W1985303224 cites W2156726032 @default.
- W1985303224 cites W2164619944 @default.
- W1985303224 cites W2167184077 @default.
- W1985303224 cites W2169425378 @default.
- W1985303224 doi "https://doi.org/10.1073/pnas.0609100104" @default.
- W1985303224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1820674" @default.
- W1985303224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17360443" @default.
- W1985303224 hasPublicationYear "2007" @default.
- W1985303224 type Work @default.
- W1985303224 sameAs 1985303224 @default.
- W1985303224 citedByCount "158" @default.
- W1985303224 countsByYear W19853032242012 @default.
- W1985303224 countsByYear W19853032242013 @default.
- W1985303224 countsByYear W19853032242014 @default.
- W1985303224 countsByYear W19853032242015 @default.
- W1985303224 countsByYear W19853032242016 @default.
- W1985303224 countsByYear W19853032242017 @default.
- W1985303224 countsByYear W19853032242018 @default.
- W1985303224 countsByYear W19853032242019 @default.
- W1985303224 countsByYear W19853032242020 @default.
- W1985303224 countsByYear W19853032242021 @default.
- W1985303224 countsByYear W19853032242022 @default.
- W1985303224 countsByYear W19853032242023 @default.
- W1985303224 crossrefType "journal-article" @default.
- W1985303224 hasAuthorship W1985303224A5009263498 @default.
- W1985303224 hasAuthorship W1985303224A5012528142 @default.
- W1985303224 hasAuthorship W1985303224A5016781421 @default.
- W1985303224 hasAuthorship W1985303224A5024722455 @default.
- W1985303224 hasAuthorship W1985303224A5043760837 @default.
- W1985303224 hasAuthorship W1985303224A5051287989 @default.
- W1985303224 hasAuthorship W1985303224A5057184445 @default.
- W1985303224 hasAuthorship W1985303224A5066413760 @default.
- W1985303224 hasAuthorship W1985303224A5070434265 @default.
- W1985303224 hasBestOaLocation W19853032241 @default.
- W1985303224 hasConcept C104317684 @default.
- W1985303224 hasConcept C129536746 @default.
- W1985303224 hasConcept C137620995 @default.
- W1985303224 hasConcept C145103041 @default.
- W1985303224 hasConcept C196843134 @default.
- W1985303224 hasConcept C207200792 @default.
- W1985303224 hasConcept C2777164004 @default.
- W1985303224 hasConcept C2780915607 @default.
- W1985303224 hasConcept C3763915 @default.
- W1985303224 hasConcept C54355233 @default.
- W1985303224 hasConcept C62478195 @default.
- W1985303224 hasConcept C66332042 @default.