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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985303663> ?p ?o ?g. }

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• W1985303663 abstract "Two series of quinoline derivatives bearing the pyridine/pyrimidine scaffold were synthesized, and evaluated for their c-Met kinase inhibitory activity and antiproliferative activity against 5 cancer cell lines (HT-29, H460, MKN-45, A549, and U87MG) were evaluated in vitro. Most compounds showed moderate to excellent potency, and compared to foretinib, the most promising analog 18b (c-Met half-maximal inhibitory concentration [IC50] = 1.39 nM) showed a 7.3-fold increase in activity against HT-29 cell line in vitro. Structure–activity relationship studies indicated that regulation of the electron density on the pyridine/pyrimidine ring to a proper degree was a key factor in improving the antitumor activity." @default.
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• W1985303663 date "2013-11-01" @default.
• W1985303663 modified "2023-10-06" @default.
• W1985303663 title "Design, synthesis, and structure–activity relationships of novel 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents" @default.
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• W1985303663 doi "https://doi.org/10.1016/j.ejmech.2013.08.019" @default.
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