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• W1985332683 abstract "There is a rising interest towards the old drug, nicotinic acid (niacin, vitamin B(3)), because at pharmacological concentrations it has a beneficial effect on HDL cholesterol. Its use, however, was limited due to its adverse effect, flushing. When the mechanism of flushing was solved, a combination of niacin and DP1 receptor antagonist or prostaglandin inhibitor is used, there has been a comeback of niacin with extensive clinical trials. This paper argues that the new strategy with niacin for the prevention of atherosclerosis should be re-evaluated, because vasodilatation of the peripheral vessels might be crucially important in the early primary prevention according to our vasa vasorum hypoxia hypothesis." @default.
• W1985332683 created "2016-06-24" @default.
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• W1985332683 date "2010-10-01" @default.
• W1985332683 modified "2023-10-17" @default.
• W1985332683 title "Niacin in the prevention of atherosclerosis: Significance of vasodilatation" @default.
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• W1985332683 doi "https://doi.org/10.1016/j.mehy.2010.04.007" @default.
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