FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985334413> ?p ?o ?g. }

• W1985334413 endingPage "992" @default.
• W1985334413 startingPage "975" @default.
• W1985334413 abstract "Hair cell death is a major cause of hearing impairment. Preservation of surface barrier upon hair cell loss is critical to prevent leakage of potassium-rich endolymph into the organ of Corti and to prevent expansion of cellular damage. Understanding of wound healing in this cytoarchitecturally complex organ requires ultrastructural 3D visualization. Powered by the serial block-face scanning electron microscopy, we penetrate into the cell biological mechanisms in the acute response of outer hair cells and glial-like Deiters' cells to ototoxic trauma in vivo. We show that Deiters' cells function as phagocytes. Upon trauma, their phalangeal processes swell and the resulting close cellular contacts allow engulfment of apoptotic cell debris. Apical domains of dying hair cells are eliminated from the inner ear sensory epithelia, an event thought to depend on supporting cells' actomyosin contractile activity. We show that in the case of apoptotic outer hair cells of the organ of Corti, elimination of their apices is preceded by strong cell body shrinkage, emphasizing the role of the dying cell itself in the cleavage. Our data reveal that the resealing of epithelial surface by junctional extensions of Deiters' cells is dynamically reinforced by newly polymerized F-actin belts. By analyzing Cdc42-inactivated Deiters' cells with defects in actin dynamics and surface closure, we show that compromised barrier integrity shifts hair cell death from apoptosis to necrosis and leads to expanded hair cell and nerve fiber damage. Our results have implications concerning therapeutic protective and regenerative interventions, because both interventions should maintain barrier integrity." @default.
• W1985334413 created "2016-06-24" @default.
• W1985334413 creator A5002633839 @default.
• W1985334413 creator A5007270321 @default.
• W1985334413 creator A5015335572 @default.
• W1985334413 creator A5051320433 @default.
• W1985334413 creator A5058389354 @default.
• W1985334413 creator A5071433852 @default.
• W1985334413 creator A5089430130 @default.
• W1985334413 date "2014-07-30" @default.
• W1985334413 modified "2023-10-18" @default.
• W1985334413 title "How to Bury the Dead: Elimination of Apoptotic Hair Cells from the Hearing Organ of the Mouse" @default.
• W1985334413 cites W1564132320 @default.
• W1985334413 cites W1965099938 @default.
• W1985334413 cites W1972200274 @default.
• W1985334413 cites W1972509102 @default.
• W1985334413 cites W1975523864 @default.
• W1985334413 cites W1976381150 @default.
• W1985334413 cites W1982171596 @default.
• W1985334413 cites W1986047072 @default.
• W1985334413 cites W1986802403 @default.
• W1985334413 cites W1989635878 @default.
• W1985334413 cites W1994923315 @default.
• W1985334413 cites W2008422345 @default.
• W1985334413 cites W2020549109 @default.
• W1985334413 cites W2029861821 @default.
• W1985334413 cites W2030239298 @default.
• W1985334413 cites W2031735932 @default.
• W1985334413 cites W2032078116 @default.
• W1985334413 cites W2038665424 @default.
• W1985334413 cites W2041056751 @default.
• W1985334413 cites W2042690085 @default.
• W1985334413 cites W2064657201 @default.
• W1985334413 cites W2070008128 @default.
• W1985334413 cites W2072895389 @default.
• W1985334413 cites W2075373281 @default.
• W1985334413 cites W2077886251 @default.
• W1985334413 cites W2078219208 @default.
• W1985334413 cites W2089603629 @default.
• W1985334413 cites W2090114628 @default.
• W1985334413 cites W2091640904 @default.
• W1985334413 cites W2099243834 @default.
• W1985334413 cites W2099771668 @default.
• W1985334413 cites W2102941077 @default.
• W1985334413 cites W2104463355 @default.
• W1985334413 cites W2105093304 @default.
• W1985334413 cites W2105799240 @default.
• W1985334413 cites W2113829302 @default.
• W1985334413 cites W2115403023 @default.
• W1985334413 cites W2121405816 @default.
• W1985334413 cites W2122317430 @default.
• W1985334413 cites W2135484463 @default.
• W1985334413 cites W2137150431 @default.
• W1985334413 cites W2143454033 @default.
• W1985334413 cites W2146247758 @default.
• W1985334413 cites W2167158605 @default.
• W1985334413 cites W2171363772 @default.
• W1985334413 cites W2409907282 @default.
• W1985334413 cites W4300465941 @default.
• W1985334413 doi "https://doi.org/10.1007/s10162-014-0480-x" @default.
• W1985334413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4389953" @default.
• W1985334413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25074370" @default.
• W1985334413 hasPublicationYear "2014" @default.
• W1985334413 type Work @default.
• W1985334413 sameAs 1985334413 @default.
• W1985334413 citedByCount "49" @default.
• W1985334413 countsByYear W19853344132014 @default.
• W1985334413 countsByYear W19853344132015 @default.
• W1985334413 countsByYear W19853344132016 @default.
• W1985334413 countsByYear W19853344132017 @default.
• W1985334413 countsByYear W19853344132018 @default.
• W1985334413 countsByYear W19853344132019 @default.
• W1985334413 countsByYear W19853344132020 @default.
• W1985334413 countsByYear W19853344132021 @default.
• W1985334413 countsByYear W19853344132022 @default.
• W1985334413 countsByYear W19853344132023 @default.
• W1985334413 crossrefType "journal-article" @default.
• W1985334413 hasAuthorship W1985334413A5002633839 @default.
• W1985334413 hasAuthorship W1985334413A5007270321 @default.
• W1985334413 hasAuthorship W1985334413A5015335572 @default.
• W1985334413 hasAuthorship W1985334413A5051320433 @default.
• W1985334413 hasAuthorship W1985334413A5058389354 @default.
• W1985334413 hasAuthorship W1985334413A5071433852 @default.
• W1985334413 hasAuthorship W1985334413A5089430130 @default.
• W1985334413 hasBestOaLocation W19853344132 @default.
• W1985334413 hasConcept C105702510 @default.
• W1985334413 hasConcept C142724271 @default.
• W1985334413 hasConcept C185592680 @default.
• W1985334413 hasConcept C190283241 @default.
• W1985334413 hasConcept C2778500370 @default.
• W1985334413 hasConcept C2778585322 @default.
• W1985334413 hasConcept C2780130748 @default.
• W1985334413 hasConcept C2780659331 @default.
• W1985334413 hasConcept C31573885 @default.
• W1985334413 hasConcept C55493867 @default.
• W1985334413 hasConcept C71924100 @default.
• W1985334413 hasConcept C86803240 @default.
• W1985334413 hasConcept C95444343 @default.

• next