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• W1985336724 endingPage "726" @default.
• W1985336724 startingPage "714" @default.
• W1985336724 abstract "Tissue-specific expression of the mammalian FTZ-F1 gene is essential for adrenal and gonadal development and sexual differentiation. The FTZ-F1 gene encodes an orphan nuclear receptor, termed SF-1 (steroidogenic factor-1) or Ad4BP, which is a primary transcriptional regulator of several hormone and steroidogenic enzyme genes that are critical for normal physiological function of the hypothalamic-pituitary-gonadal axis in reproduction. The objective of the current study is to understand the molecular mechanisms underlying transcriptional regulation of SF-1 gene expression in the pituitary. We have studied a series of deletion and point mutations in the SF-1 promoter region for transcriptional activity in alphaT3-1 and L/betaT2 (pituitary gonadotrope), CV-1, JEG-3, and Y1 (adrenocortical) cell lines. Our results indicate that maximal expression of the SF-1 promoter in all cell types requires an E box element at -82/-77. This E box sequence (CACGTG) is identical to the binding element for USF (upstream stimulatory factor), a member of the helix-loop-helix family of transcription factors. Studies of the SF-1 gene E box element using gel mobility shift and antibody supershift assays indicate that USF may be a key transcriptional regulator of SF-1 gene expression." @default.
• W1985336724 created "2016-06-24" @default.
• W1985336724 creator A5050968979 @default.
• W1985336724 creator A5063307434 @default.
• W1985336724 date "1998-05-01" @default.
• W1985336724 modified "2023-09-23" @default.
• W1985336724 title "The Basic Helix-Loop-Helix, Leucine Zipper Transcription Factor, USF (Upstream Stimulatory Factor), Is a Key Regulator of SF-1 (Steroidogenic Factor-1) Gene Expression in Pituitary Gonadotrope and Steroidogenic Cells" @default.
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• W1985336724 doi "https://doi.org/10.1210/mend.12.5.0100" @default.
• W1985336724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9605934" @default.
• W1985336724 hasPublicationYear "1998" @default.
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