FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985337420> ?p ?o ?g. }

• W1985337420 endingPage "165" @default.
• W1985337420 startingPage "156" @default.
• W1985337420 abstract "Previous work on vitamin D in the prostate has focused on the prostatic epithelium, from which prostate cancer arises. Prostatic epithelial cells are surrounded by stroma, which has well-established regulatory control over epithelial proliferation, differentiation, and the inflammatory response. Here we examined the regulation of vitamin D-related genes and inflammatory genes by 1α,25-dihydroxyvitamin D3 (1,25(OH)2D) in laser-capture microdissected prostate tissue from a vitamin D3 clinical trial and in an in vitro model that facilitates stromal-epithelial crosstalk. Analysis of the trial tissues showed that VDR was present in both cell types, whereas expression of the hydroxylases was the highest in the epithelium. Examination of gene expression by prostatic (1,25(OH)2D) concentrations showed that VDR was significantly lower in prostate tissues with the highest concentration of 1,25(OH)2D, and down-regulation of VDR by 1,25(OH) 2D was confirmed in the primary cell cultures. Analysis of inflammatory genes in the patient tissues revealed that IL-6 expression was the highest in the prostate stroma while PTGS2 (COX2) levels were lowest in the prostate cancer tissues from men in the highest tertile of prostatic 1,25(OH)2D. In vitro, TNF-α, IL-6 and IL-8 were suppressed by 1,25 (OH)2D in the primary epithelial cells, whereas TNF-α and PTGS2 were suppressed by 1,25(OH) 2D in the stromal cells. Importantly, the ability of 1,25(OH)2D to alter pro-inflammatory-induced changes in epithelial cell growth were dependent on the presence of the stromal cells. In summary, whereas both stromal and epithelial cells of the prostate express VDR and can presumably respond to 1,25(OH)2D, the prostatic epithelium appears to be the main producer of 1,25(OH)2D. Further, while the prostate epithelium was more responsive to the anti-inflammatory activity of 1,25 (OH)2D than stromal cells, stroma-epithelial crosstalk enhanced the phenotypic effects of 1,25(OH)2D and the inflammatory process in the prostate gland." @default.
• W1985337420 created "2016-06-24" @default.
• W1985337420 creator A5019107791 @default.
• W1985337420 creator A5032837237 @default.
• W1985337420 creator A5049719845 @default.
• W1985337420 creator A5057500759 @default.
• W1985337420 creator A5077667373 @default.
• W1985337420 creator A5082800651 @default.
• W1985337420 creator A5085358872 @default.
• W1985337420 date "2015-04-01" @default.
• W1985337420 modified "2023-09-26" @default.
• W1985337420 title "Differential expression and regulation of vitamin D hydroxylases and inflammatory genes in prostate stroma and epithelium by 1,25-dihydroxyvitamin D in men with prostate cancer and an in vitro model" @default.
• W1985337420 cites W1581834767 @default.
• W1985337420 cites W1762202522 @default.
• W1985337420 cites W1911919368 @default.
• W1985337420 cites W1970094818 @default.
• W1985337420 cites W1974449618 @default.
• W1985337420 cites W1979869077 @default.
• W1985337420 cites W1998843836 @default.
• W1985337420 cites W2001148099 @default.
• W1985337420 cites W2002352068 @default.
• W1985337420 cites W2003832876 @default.
• W1985337420 cites W2010841793 @default.
• W1985337420 cites W2018371450 @default.
• W1985337420 cites W2020168124 @default.
• W1985337420 cites W2020994990 @default.
• W1985337420 cites W2025179609 @default.
• W1985337420 cites W2027882565 @default.
• W1985337420 cites W2034564140 @default.
• W1985337420 cites W2040398116 @default.
• W1985337420 cites W2043812762 @default.
• W1985337420 cites W2051131004 @default.
• W1985337420 cites W2052273673 @default.
• W1985337420 cites W2059193476 @default.
• W1985337420 cites W2062809449 @default.
• W1985337420 cites W2065078105 @default.
• W1985337420 cites W2068081568 @default.
• W1985337420 cites W2070191400 @default.
• W1985337420 cites W2070852249 @default.
• W1985337420 cites W2071117491 @default.
• W1985337420 cites W2074168165 @default.
• W1985337420 cites W2086478724 @default.
• W1985337420 cites W2088146533 @default.
• W1985337420 cites W2090772441 @default.
• W1985337420 cites W2091214366 @default.
• W1985337420 cites W2094640589 @default.
• W1985337420 cites W2101305429 @default.
• W1985337420 cites W2123857513 @default.
• W1985337420 cites W2124394051 @default.
• W1985337420 cites W2130268646 @default.
• W1985337420 cites W2150794592 @default.
• W1985337420 cites W2155354626 @default.
• W1985337420 cites W2161882037 @default.
• W1985337420 cites W2164097156 @default.
• W1985337420 cites W2165555606 @default.
• W1985337420 cites W4376849648 @default.
• W1985337420 doi "https://doi.org/10.1016/j.jsbmb.2014.10.004" @default.
• W1985337420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4361379" @default.
• W1985337420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25305352" @default.
• W1985337420 hasPublicationYear "2015" @default.
• W1985337420 type Work @default.
• W1985337420 sameAs 1985337420 @default.
• W1985337420 citedByCount "36" @default.
• W1985337420 countsByYear W19853374202015 @default.
• W1985337420 countsByYear W19853374202016 @default.
• W1985337420 countsByYear W19853374202017 @default.
• W1985337420 countsByYear W19853374202018 @default.
• W1985337420 countsByYear W19853374202019 @default.
• W1985337420 countsByYear W19853374202020 @default.
• W1985337420 countsByYear W19853374202021 @default.
• W1985337420 countsByYear W19853374202022 @default.
• W1985337420 countsByYear W19853374202023 @default.
• W1985337420 crossrefType "journal-article" @default.
• W1985337420 hasAuthorship W1985337420A5019107791 @default.
• W1985337420 hasAuthorship W1985337420A5032837237 @default.
• W1985337420 hasAuthorship W1985337420A5049719845 @default.
• W1985337420 hasAuthorship W1985337420A5057500759 @default.
• W1985337420 hasAuthorship W1985337420A5077667373 @default.
• W1985337420 hasAuthorship W1985337420A5082800651 @default.
• W1985337420 hasAuthorship W1985337420A5085358872 @default.
• W1985337420 hasBestOaLocation W19853374202 @default.
• W1985337420 hasConcept C121608353 @default.
• W1985337420 hasConcept C124490489 @default.
• W1985337420 hasConcept C126322002 @default.
• W1985337420 hasConcept C134018914 @default.
• W1985337420 hasConcept C16930146 @default.
• W1985337420 hasConcept C179639408 @default.
• W1985337420 hasConcept C204232928 @default.
• W1985337420 hasConcept C2776235491 @default.
• W1985337420 hasConcept C2780192828 @default.
• W1985337420 hasConcept C502942594 @default.
• W1985337420 hasConcept C52124034 @default.
• W1985337420 hasConcept C529295009 @default.
• W1985337420 hasConcept C54355233 @default.
• W1985337420 hasConcept C71924100 @default.
• W1985337420 hasConcept C86803240 @default.
• W1985337420 hasConceptScore W1985337420C121608353 @default.
• W1985337420 hasConceptScore W1985337420C124490489 @default.

• next