FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985338503> ?p ?o ?g. }

• W1985338503 abstract "Ewing sarcoma family of tumors (ESFT), characterized by t(11;22)(q24;q12), is one of the most common tumors of bone in children and young adults. In addition to EWS/FLI1 gene fusion, copy number changes are known to be significant for the underlying neoplastic development of ESFT and for patient outcome. Our genome-wide high-resolution analysis aspired to pinpoint genomic regions of highest interest and possible target genes in these areas. Array comparative genomic hybridization (CGH) and expression arrays were used to screen for copy number alterations and expression changes in ESFT patient samples. A total of 31 ESFT samples were analyzed by aCGH and in 16 patients DNA and RNA level data, created by expression arrays, was integrated. Time of the follow-up of these patients was 5–192 months. Clinical outcome was statistically evaluated by Kaplan-Meier/Logrank methods and RT-PCR was applied on 42 patient samples to study the gene of the highest interest. Copy number changes were detected in 87% of the cases. The most recurrent copy number changes were gains at 1q, 2, 8, and 12, and losses at 9p and 16q. Cumulative event free survival (ESFT) and overall survival (OS) were significantly better (P < 0.05) for primary tumors with three or less copy number changes than for tumors with higher number of copy number aberrations. In three samples copy number imbalances were detected in chromosomes 11 and 22 affecting the FLI1 and EWSR1 loci, suggesting that an unbalanced t(11;22) and subsequent duplication of the derivative chromosome harboring fusion gene is a common event in ESFT. Further, amplifications on chromosomes 20 and 22 seen in one patient sample suggest a novel translocation type between EWSR1 and an unidentified fusion partner at 20q. In total 20 novel ESFT associated putative oncogenes and tumor suppressor genes were found in the integration analysis of array CGH and expression data. Quantitative RT-PCR to study the expression levels of the most interesting gene, HDGF, confirmed that its expression was higher than in control samples. However, no association between HDGF expression and patient survival was observed. We conclude that array CGH and integration analysis proved to be effective methods to identify chromosome regions and novel target genes involved in the tumorigenesis of ESFT." @default.
• W1985338503 created "2016-06-24" @default.
• W1985338503 creator A5015636061 @default.
• W1985338503 creator A5018305257 @default.
• W1985338503 creator A5019040135 @default.
• W1985338503 creator A5021826007 @default.
• W1985338503 creator A5022563430 @default.
• W1985338503 creator A5029689310 @default.
• W1985338503 creator A5035392874 @default.
• W1985338503 creator A5074174264 @default.
• W1985338503 creator A5083948167 @default.
• W1985338503 creator A5084783731 @default.
• W1985338503 date "2009-01-14" @default.
• W1985338503 modified "2023-09-27" @default.
• W1985338503 title "Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors" @default.
• W1985338503 cites W139170164 @default.
• W1985338503 cites W1750544312 @default.
• W1985338503 cites W192341775 @default.
• W1985338503 cites W1964403040 @default.
• W1985338503 cites W1964895626 @default.
• W1985338503 cites W1967351618 @default.
• W1985338503 cites W1974105816 @default.
• W1985338503 cites W1975964692 @default.
• W1985338503 cites W1981571109 @default.
• W1985338503 cites W1986261989 @default.
• W1985338503 cites W1993231922 @default.
• W1985338503 cites W2000061217 @default.
• W1985338503 cites W2000894855 @default.
• W1985338503 cites W2004163775 @default.
• W1985338503 cites W2007403856 @default.
• W1985338503 cites W2011216044 @default.
• W1985338503 cites W2014120165 @default.
• W1985338503 cites W2016195496 @default.
• W1985338503 cites W2017609883 @default.
• W1985338503 cites W2017702964 @default.
• W1985338503 cites W2019034074 @default.
• W1985338503 cites W2025645148 @default.
• W1985338503 cites W2030988924 @default.
• W1985338503 cites W2033604705 @default.
• W1985338503 cites W2048248253 @default.
• W1985338503 cites W2050106965 @default.
• W1985338503 cites W2058974349 @default.
• W1985338503 cites W2065005324 @default.
• W1985338503 cites W2069351898 @default.
• W1985338503 cites W2078744165 @default.
• W1985338503 cites W2084619475 @default.
• W1985338503 cites W2084957323 @default.
• W1985338503 cites W2091247337 @default.
• W1985338503 cites W2093376914 @default.
• W1985338503 cites W2101392213 @default.
• W1985338503 cites W2107277218 @default.
• W1985338503 cites W2121294571 @default.
• W1985338503 cites W2122532981 @default.
• W1985338503 cites W2131883841 @default.
• W1985338503 cites W2135275823 @default.
• W1985338503 cites W2135488124 @default.
• W1985338503 cites W2136182072 @default.
• W1985338503 cites W2140423522 @default.
• W1985338503 cites W2155513152 @default.
• W1985338503 cites W2157282246 @default.
• W1985338503 cites W2160237840 @default.
• W1985338503 cites W2162996009 @default.
• W1985338503 cites W2224371109 @default.
• W1985338503 cites W2409198636 @default.
• W1985338503 cites W2463686631 @default.
• W1985338503 cites W4376542646 @default.
• W1985338503 doi "https://doi.org/10.1186/1471-2407-9-17" @default.
• W1985338503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2633345" @default.
• W1985338503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19144156" @default.
• W1985338503 hasPublicationYear "2009" @default.
• W1985338503 type Work @default.
• W1985338503 sameAs 1985338503 @default.
• W1985338503 citedByCount "60" @default.
• W1985338503 countsByYear W19853385032012 @default.
• W1985338503 countsByYear W19853385032013 @default.
• W1985338503 countsByYear W19853385032014 @default.
• W1985338503 countsByYear W19853385032015 @default.
• W1985338503 countsByYear W19853385032016 @default.
• W1985338503 countsByYear W19853385032017 @default.
• W1985338503 countsByYear W19853385032018 @default.
• W1985338503 countsByYear W19853385032019 @default.
• W1985338503 countsByYear W19853385032020 @default.
• W1985338503 countsByYear W19853385032022 @default.
• W1985338503 crossrefType "journal-article" @default.
• W1985338503 hasAuthorship W1985338503A5015636061 @default.
• W1985338503 hasAuthorship W1985338503A5018305257 @default.
• W1985338503 hasAuthorship W1985338503A5019040135 @default.
• W1985338503 hasAuthorship W1985338503A5021826007 @default.
• W1985338503 hasAuthorship W1985338503A5022563430 @default.
• W1985338503 hasAuthorship W1985338503A5029689310 @default.
• W1985338503 hasAuthorship W1985338503A5035392874 @default.
• W1985338503 hasAuthorship W1985338503A5074174264 @default.
• W1985338503 hasAuthorship W1985338503A5083948167 @default.
• W1985338503 hasAuthorship W1985338503A5084783731 @default.
• W1985338503 hasBestOaLocation W19853385031 @default.
• W1985338503 hasConcept C104317684 @default.
• W1985338503 hasConcept C10515644 @default.
• W1985338503 hasConcept C111829193 @default.
• W1985338503 hasConcept C120821319 @default.
• W1985338503 hasConcept C124942203 @default.

• next