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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985340505> ?p ?o ?g. }

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• W1985340505 startingPage "11481" @default.
• W1985340505 abstract "Enhancement of the defensive withdrawal reflex of Aplysia involves a prolongation of the action potentials of mechanosensory neurons, which contributes to facilitation of transmitter release from these cells. Recent reports have suggested that whereas cAMP-dependent modulation of K+ current increases sensory neuron excitability, a cAMP-independent decrease in K+ current may increase the action potential duration and, thus, facilitate transmitter release. We have tested this proposal using Walsh cAMP-dependent protein kinase inhibitor or activators of the cAMP cascade and found that cAMP plays a major role in the spike-broadening effects of facilitatory transmitter; however, broadening requires higher levels of activation of the cAMP-dependent kinase than does increasing excitability. A steeply voltage-dependent transient K+ current, termed IKV,early, and the slowly activating S-type K+ (S-K+) current are both reduced by activation of the cAMP cascade, although with different sensitivities to the second messenger, enabling excitability and spike duration to be regulated independently. Differences in cAMP sensitivity also suggested that the originally described S-K+ current actually consists of two independent components, a slowly activating component and a time-independent, steady-state current that is activated at rest." @default.
• W1985340505 created "2016-06-24" @default.
• W1985340505 creator A5033099125 @default.
• W1985340505 creator A5033877762 @default.
• W1985340505 date "1992-12-01" @default.
• W1985340505 modified "2023-10-18" @default.
• W1985340505 title "cAMP modulates multiple K+ currents, increasing spike duration and excitability in Aplysia sensory neurons." @default.
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• W1985340505 doi "https://doi.org/10.1073/pnas.89.23.11481" @default.
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