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- W1985340919 abstract "Several non-steroidal anti-inflammatory agents (NSAIA) are shown to inhibit the net production of prostaglandin (PG)- like activity from arachidonic acid by a cell-free preparation of guinea-pig lung. Moreover, these agents also antagonize PGE1-induced contractions of the isolated gerbil colon. The anti-spasmogenic effects are reversible and specific. At high concentrations, indomethacin and mefenamic acid interfere with the binding of PGE1 to a broken cell preparation of rat epididymal adipocytes. Taken together the data indicate that NSAIA interact with prostaglandins at multiple sites and are consistent with the suggestions reported previously that NSAIA may have multiple in vivo actions." @default.
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- W1985340919 date "1975-03-01" @default.
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- W1985340919 title "Multiple sites of interaction between prostaglandins and non-steroidal anti-inflammatory agents" @default.
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- W1985340919 doi "https://doi.org/10.1016/0090-6980(75)90139-2" @default.
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