Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985352714> ?p ?o ?g. }
- W1985352714 endingPage "4056" @default.
- W1985352714 startingPage "4053" @default.
- W1985352714 abstract "Based on the favorable antiviral profiles of 4′-substituted nucleosides, novel 1-(2′-deoxy-2′-fluoro-4′-C-ethynyl-β-d-arabinofuranosyl)-uracil (1a), -thymine (1b), and -cytosine (2) analogs were synthesized. Compounds 1b and 2 exhibited potent anti-HIV-1 activity with IC50 values of 86 and 1.34 nM, respectively, without significant cytotoxicity. Compound 2 was 35-fold more potent than AZT against wild-type virus, and also retained nanomolar antiviral activity against resistant strains, NL4-3 (K101E) and RTMDR. Thus, 2 merits further development as a novel NRTI drug." @default.
- W1985352714 created "2016-06-24" @default.
- W1985352714 creator A5020603394 @default.
- W1985352714 creator A5026429037 @default.
- W1985352714 creator A5027971282 @default.
- W1985352714 creator A5035501576 @default.
- W1985352714 creator A5046695443 @default.
- W1985352714 creator A5067500491 @default.
- W1985352714 creator A5086524428 @default.
- W1985352714 date "2010-07-01" @default.
- W1985352714 modified "2023-10-01" @default.
- W1985352714 title "Synthesis and anti-HIV activity of 2′-deoxy-2′-fluoro-4′-C-ethynyl nucleoside analogs" @default.
- W1985352714 cites W1925504181 @default.
- W1985352714 cites W1976580962 @default.
- W1985352714 cites W1985977968 @default.
- W1985352714 cites W1991600027 @default.
- W1985352714 cites W1994082151 @default.
- W1985352714 cites W1997448570 @default.
- W1985352714 cites W2034877754 @default.
- W1985352714 cites W2058266820 @default.
- W1985352714 cites W2059679474 @default.
- W1985352714 cites W2072901265 @default.
- W1985352714 cites W2073434078 @default.
- W1985352714 cites W2073593530 @default.
- W1985352714 cites W2083470546 @default.
- W1985352714 cites W2086186867 @default.
- W1985352714 cites W2094811518 @default.
- W1985352714 cites W2121527865 @default.
- W1985352714 cites W2140534639 @default.
- W1985352714 cites W2143773220 @default.
- W1985352714 cites W2143788821 @default.
- W1985352714 cites W2146930911 @default.
- W1985352714 cites W2176031779 @default.
- W1985352714 doi "https://doi.org/10.1016/j.bmcl.2010.05.090" @default.
- W1985352714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2915458" @default.
- W1985352714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20542430" @default.
- W1985352714 hasPublicationYear "2010" @default.
- W1985352714 type Work @default.
- W1985352714 sameAs 1985352714 @default.
- W1985352714 citedByCount "23" @default.
- W1985352714 countsByYear W19853527142012 @default.
- W1985352714 countsByYear W19853527142013 @default.
- W1985352714 countsByYear W19853527142014 @default.
- W1985352714 countsByYear W19853527142015 @default.
- W1985352714 countsByYear W19853527142017 @default.
- W1985352714 countsByYear W19853527142019 @default.
- W1985352714 countsByYear W19853527142020 @default.
- W1985352714 countsByYear W19853527142022 @default.
- W1985352714 countsByYear W19853527142023 @default.
- W1985352714 crossrefType "journal-article" @default.
- W1985352714 hasAuthorship W1985352714A5020603394 @default.
- W1985352714 hasAuthorship W1985352714A5026429037 @default.
- W1985352714 hasAuthorship W1985352714A5027971282 @default.
- W1985352714 hasAuthorship W1985352714A5035501576 @default.
- W1985352714 hasAuthorship W1985352714A5046695443 @default.
- W1985352714 hasAuthorship W1985352714A5067500491 @default.
- W1985352714 hasAuthorship W1985352714A5086524428 @default.
- W1985352714 hasBestOaLocation W19853527142 @default.
- W1985352714 hasConcept C109316439 @default.
- W1985352714 hasConcept C114373084 @default.
- W1985352714 hasConcept C116073593 @default.
- W1985352714 hasConcept C159047783 @default.
- W1985352714 hasConcept C185592680 @default.
- W1985352714 hasConcept C193042331 @default.
- W1985352714 hasConcept C202751555 @default.
- W1985352714 hasConcept C2522874641 @default.
- W1985352714 hasConcept C2776023528 @default.
- W1985352714 hasConcept C2776543447 @default.
- W1985352714 hasConcept C2776858809 @default.
- W1985352714 hasConcept C2777333352 @default.
- W1985352714 hasConcept C2777752112 @default.
- W1985352714 hasConcept C2777752497 @default.
- W1985352714 hasConcept C2779554091 @default.
- W1985352714 hasConcept C552990157 @default.
- W1985352714 hasConcept C55493867 @default.
- W1985352714 hasConcept C71240020 @default.
- W1985352714 hasConcept C86803240 @default.
- W1985352714 hasConceptScore W1985352714C109316439 @default.
- W1985352714 hasConceptScore W1985352714C114373084 @default.
- W1985352714 hasConceptScore W1985352714C116073593 @default.
- W1985352714 hasConceptScore W1985352714C159047783 @default.
- W1985352714 hasConceptScore W1985352714C185592680 @default.
- W1985352714 hasConceptScore W1985352714C193042331 @default.
- W1985352714 hasConceptScore W1985352714C202751555 @default.
- W1985352714 hasConceptScore W1985352714C2522874641 @default.
- W1985352714 hasConceptScore W1985352714C2776023528 @default.
- W1985352714 hasConceptScore W1985352714C2776543447 @default.
- W1985352714 hasConceptScore W1985352714C2776858809 @default.
- W1985352714 hasConceptScore W1985352714C2777333352 @default.
- W1985352714 hasConceptScore W1985352714C2777752112 @default.
- W1985352714 hasConceptScore W1985352714C2777752497 @default.
- W1985352714 hasConceptScore W1985352714C2779554091 @default.
- W1985352714 hasConceptScore W1985352714C552990157 @default.
- W1985352714 hasConceptScore W1985352714C55493867 @default.
- W1985352714 hasConceptScore W1985352714C71240020 @default.
- W1985352714 hasConceptScore W1985352714C86803240 @default.
- W1985352714 hasFunder F4320321001 @default.
- W1985352714 hasFunder F4320337355 @default.