FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985360090> ?p ?o ?g. }

• W1985360090 endingPage "47" @default.
• W1985360090 startingPage "39" @default.
• W1985360090 abstract "Abstract Purpose: Progression to the castration-resistant state is the incurable and lethal end stage of prostate cancer, and there is strong evidence that androgen receptor (AR) still plays a central role in this process. We hypothesize that knocking down AR will have a major effect on inhibiting growth of castration-resistant tumors. Experimental Design: Castration-resistant C4-2 human prostate cancer cells stably expressing a tetracycline-inducible AR-targeted short hairpin RNA (shRNA) were generated to directly test the effects of AR knockdown in C4-2 human prostate cancer cells and tumors. Results: In vitro expression of AR shRNA resulted in decreased levels of AR mRNA and protein, decreased expression of prostate-specific antigen (PSA), reduced activation of the PSA-luciferase reporter, and growth inhibition of C4-2 cells. Gene microarray analyses revealed that AR knockdown under hormone-deprived conditions resulted in activation of genes involved in apoptosis, cell cycle regulation, protein synthesis, and tumorigenesis. To ensure that tumors were truly castration-resistant in vivo, inducible AR shRNA expressing C4-2 tumors were grown in castrated mice to an average volume of 450 mm3. In all of the animals, serum PSA decreased, and in 50% of them, there was complete tumor regression and disappearance of serum PSA. Conclusions: Whereas castration is ineffective in castration-resistant prostate tumors, knockdown of AR can decrease serum PSA, inhibit tumor growth, and frequently cause tumor regression. This study is the first direct evidence that knockdown of AR is a viable therapeutic strategy for treatment of prostate tumors that have already progressed to the castration-resistant state." @default.
• W1985360090 created "2016-06-24" @default.
• W1985360090 creator A5008699306 @default.
• W1985360090 creator A5012065316 @default.
• W1985360090 creator A5032435355 @default.
• W1985360090 creator A5034110828 @default.
• W1985360090 creator A5058530861 @default.
• W1985360090 creator A5062125605 @default.
• W1985360090 creator A5065365130 @default.
• W1985360090 creator A5074731511 @default.
• W1985360090 creator A5077669541 @default.
• W1985360090 creator A5089480920 @default.
• W1985360090 date "2008-12-31" @default.
• W1985360090 modified "2023-10-18" @default.
• W1985360090 title "<i>In vivo</i> Knockdown of the Androgen Receptor Results in Growth Inhibition and Regression of Well-Established, Castration-Resistant Prostate Tumors" @default.
• W1985360090 cites W1965734230 @default.
• W1985360090 cites W1972940108 @default.
• W1985360090 cites W1974810481 @default.
• W1985360090 cites W1980006154 @default.
• W1985360090 cites W1980169152 @default.
• W1985360090 cites W1989656600 @default.
• W1985360090 cites W1992079095 @default.
• W1985360090 cites W1997195909 @default.
• W1985360090 cites W2001471842 @default.
• W1985360090 cites W2003955264 @default.
• W1985360090 cites W2021117030 @default.
• W1985360090 cites W2027879081 @default.
• W1985360090 cites W2030465046 @default.
• W1985360090 cites W2037622469 @default.
• W1985360090 cites W2045075062 @default.
• W1985360090 cites W2049180642 @default.
• W1985360090 cites W2059971436 @default.
• W1985360090 cites W2063477993 @default.
• W1985360090 cites W2068319312 @default.
• W1985360090 cites W2074148448 @default.
• W1985360090 cites W2100087320 @default.
• W1985360090 cites W2103526359 @default.
• W1985360090 cites W2116801690 @default.
• W1985360090 cites W2117031581 @default.
• W1985360090 cites W2118906905 @default.
• W1985360090 cites W2120292596 @default.
• W1985360090 cites W2121158863 @default.
• W1985360090 cites W2121671287 @default.
• W1985360090 cites W2144941480 @default.
• W1985360090 cites W2150512789 @default.
• W1985360090 cites W2150775704 @default.
• W1985360090 cites W2156162122 @default.
• W1985360090 cites W2161123101 @default.
• W1985360090 cites W2163144362 @default.
• W1985360090 cites W2163285372 @default.
• W1985360090 cites W2169391650 @default.
• W1985360090 cites W2319371745 @default.
• W1985360090 doi "https://doi.org/10.1158/1078-0432.ccr-08-1726" @default.
• W1985360090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19118031" @default.
• W1985360090 hasPublicationYear "2008" @default.
• W1985360090 type Work @default.
• W1985360090 sameAs 1985360090 @default.
• W1985360090 citedByCount "127" @default.
• W1985360090 countsByYear W19853600902012 @default.
• W1985360090 countsByYear W19853600902013 @default.
• W1985360090 countsByYear W19853600902014 @default.
• W1985360090 countsByYear W19853600902015 @default.
• W1985360090 countsByYear W19853600902016 @default.
• W1985360090 countsByYear W19853600902017 @default.
• W1985360090 countsByYear W19853600902018 @default.
• W1985360090 countsByYear W19853600902019 @default.
• W1985360090 countsByYear W19853600902020 @default.
• W1985360090 countsByYear W19853600902021 @default.
• W1985360090 countsByYear W19853600902022 @default.
• W1985360090 crossrefType "journal-article" @default.
• W1985360090 hasAuthorship W1985360090A5008699306 @default.
• W1985360090 hasAuthorship W1985360090A5012065316 @default.
• W1985360090 hasAuthorship W1985360090A5032435355 @default.
• W1985360090 hasAuthorship W1985360090A5034110828 @default.
• W1985360090 hasAuthorship W1985360090A5058530861 @default.
• W1985360090 hasAuthorship W1985360090A5062125605 @default.
• W1985360090 hasAuthorship W1985360090A5065365130 @default.
• W1985360090 hasAuthorship W1985360090A5074731511 @default.
• W1985360090 hasAuthorship W1985360090A5077669541 @default.
• W1985360090 hasAuthorship W1985360090A5089480920 @default.
• W1985360090 hasBestOaLocation W19853600902 @default.
• W1985360090 hasConcept C121608353 @default.
• W1985360090 hasConcept C126322002 @default.
• W1985360090 hasConcept C173396325 @default.
• W1985360090 hasConcept C190232843 @default.
• W1985360090 hasConcept C190283241 @default.
• W1985360090 hasConcept C2776235491 @default.
• W1985360090 hasConcept C2777911890 @default.
• W1985360090 hasConcept C2779256933 @default.
• W1985360090 hasConcept C2780192828 @default.
• W1985360090 hasConcept C502942594 @default.
• W1985360090 hasConcept C55493867 @default.
• W1985360090 hasConcept C61367390 @default.
• W1985360090 hasConcept C71315377 @default.
• W1985360090 hasConcept C71924100 @default.
• W1985360090 hasConcept C86803240 @default.
• W1985360090 hasConceptScore W1985360090C121608353 @default.
• W1985360090 hasConceptScore W1985360090C126322002 @default.

• next