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- W1985360915 abstract "Piperine is the main pungent alkaloid present in the fruits of black pepper (Piper nigrum) and long pepper (Piper longum).In traditional medicine, black pepper has been used as an analgesic and anti-inflammatory agent and in the treatment of epilepsy and snake venom poisoning. Piperine also has been reported as an inhibitor against several cytochrome P-450–mediated pathways and Phase II metabolism as well as P-glycoprotein. This study was carried out to investigate the effect of piprine on the pharmacokinetics of domperidone after acute and chronic administration in rats. Animals received a single dose of domperidone (20 mg/kg, p.o.) alone or together with piperine (60 mg/kg, p.o.). Similarly, the same doses of domperidone alone or when it was given together with piperine were administered to rats chronically for 5 days. Plasma samples were collected at 0.25, 0.5, 1.0, 2.0, 3.0, 4.0, 6.0, 8.0, 10.0, and 12.0 hours after drug administration. The concentrations of domperidone in the plasma were measured using an HPLC method. The concomitant administration of piperine with domperidone acutely or chronically resulted in a significant (P < 0.05) increase in the maximum plasma concentration (Cmax), the mean area under the plasma concentration–time curve (AUC), and the elimination half-life (t½) of domperidone compared with those obtained for domperidone alone. The concurrent administration of piprine with domperidone to rats produced a significant increase in the plasma levels of the latter. However, further studies are needed to determine the possible mechanism(s) involved in this pharmacokinetic interaction." @default.
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- W1985360915 date "2013-08-01" @default.
- W1985360915 modified "2023-09-24" @default.
- W1985360915 title "PP211—Piperine Increases Plasma Domperidone Concentrations in the Rat" @default.
- W1985360915 doi "https://doi.org/10.1016/j.clinthera.2013.07.240" @default.
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