FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985364077> ?p ?o ?g. }

• W1985364077 endingPage "412" @default.
• W1985364077 startingPage "407" @default.
• W1985364077 abstract "Pyridoxal 5′-phosphate (PLP) is the biologically active form of vitamin B6 and is de novo synthesized from three substrates, dihydroxyacetone phosphate (DHAP), riburose 5-phosphate (RBP), and ammonia hydrolysed from glutamine. Glutamine amidotransferase (PdxT) catalyzes the production of ammonia from glutamine, while PdxS catalyzes the following condensation of ribulose 5-phosphate (Ru5P), glyceraldehyde-3-phosphate (G3P), and ammonia. PdxS exists as a hexamer or dodecamer depending on species and makes a 1:1 complex with PdxT. Pyrococcus horikoshii PdxS has a 37 amino acids insertion region, which is found in some archaeal PdxS proteins, but its structure and function are unknown. To provide further structural information on the role of the insertion region, the oligomeric state, and ligand binding mode of P. horikoshii PdxS, the crystal structure of PdxS from P. horikoshii was solved in two forms: (i) apo form, (ii) r ibose 5-phosphate (R5P) complex and the quaternary structure of PdxS in solution was determined by analytical gel filtration. P. horikoshii PdxS forms hexamer in solution based on analytical gel filtration data. When we superimpose the structure of P. horikoshii PdxS with other dodecamer structures of PdxS, the additional insertion is located apart from the active site and induces a steric clash on the hexamer-hexamer interface of PdxS proteins. Our results suggest that the additional insertion perturbs dodecamer formation of P. horikoshii PdxS." @default.
• W1985364077 created "2016-06-24" @default.
• W1985364077 creator A5021750295 @default.
• W1985364077 creator A5032095282 @default.
• W1985364077 creator A5060047552 @default.
• W1985364077 creator A5076264855 @default.
• W1985364077 creator A5083251665 @default.
• W1985364077 date "2012-10-01" @default.
• W1985364077 modified "2023-09-26" @default.
• W1985364077 title "Crystal structure of pyridoxal biosynthesis lyase PdxS from Pyrococcus horikoshii" @default.
• W1985364077 cites W1598516579 @default.
• W1985364077 cites W1964867612 @default.
• W1985364077 cites W1983811436 @default.
• W1985364077 cites W1995017064 @default.
• W1985364077 cites W2003045001 @default.
• W1985364077 cites W2013083986 @default.
• W1985364077 cites W2013931680 @default.
• W1985364077 cites W2019590382 @default.
• W1985364077 cites W2028689764 @default.
• W1985364077 cites W2031347822 @default.
• W1985364077 cites W2037525379 @default.
• W1985364077 cites W2043194010 @default.
• W1985364077 cites W2053636413 @default.
• W1985364077 cites W2061393819 @default.
• W1985364077 cites W2081252762 @default.
• W1985364077 cites W2097382368 @default.
• W1985364077 cites W2098287286 @default.
• W1985364077 cites W2102033493 @default.
• W1985364077 cites W2110094991 @default.
• W1985364077 cites W2118294872 @default.
• W1985364077 cites W2130830396 @default.
• W1985364077 cites W2137387674 @default.
• W1985364077 cites W2146660498 @default.
• W1985364077 cites W2163027365 @default.
• W1985364077 doi "https://doi.org/10.1007/s10059-012-0198-8" @default.
• W1985364077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3887772" @default.
• W1985364077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23104439" @default.
• W1985364077 hasPublicationYear "2012" @default.
• W1985364077 type Work @default.
• W1985364077 sameAs 1985364077 @default.
• W1985364077 citedByCount "5" @default.
• W1985364077 countsByYear W19853640772014 @default.
• W1985364077 countsByYear W19853640772015 @default.
• W1985364077 countsByYear W19853640772016 @default.
• W1985364077 countsByYear W19853640772021 @default.
• W1985364077 crossrefType "journal-article" @default.
• W1985364077 hasAuthorship W1985364077A5021750295 @default.
• W1985364077 hasAuthorship W1985364077A5032095282 @default.
• W1985364077 hasAuthorship W1985364077A5060047552 @default.
• W1985364077 hasAuthorship W1985364077A5076264855 @default.
• W1985364077 hasAuthorship W1985364077A5083251665 @default.
• W1985364077 hasBestOaLocation W19853640772 @default.
• W1985364077 hasConcept C104317684 @default.
• W1985364077 hasConcept C181199279 @default.
• W1985364077 hasConcept C185592680 @default.
• W1985364077 hasConcept C189754071 @default.
• W1985364077 hasConcept C2776943354 @default.
• W1985364077 hasConcept C2778332380 @default.
• W1985364077 hasConcept C2779349466 @default.
• W1985364077 hasConcept C35271833 @default.
• W1985364077 hasConcept C515207424 @default.
• W1985364077 hasConcept C550995028 @default.
• W1985364077 hasConcept C552990157 @default.
• W1985364077 hasConcept C55493867 @default.
• W1985364077 hasConcept C75972863 @default.
• W1985364077 hasConcept C86803240 @default.
• W1985364077 hasConceptScore W1985364077C104317684 @default.
• W1985364077 hasConceptScore W1985364077C181199279 @default.
• W1985364077 hasConceptScore W1985364077C185592680 @default.
• W1985364077 hasConceptScore W1985364077C189754071 @default.
• W1985364077 hasConceptScore W1985364077C2776943354 @default.
• W1985364077 hasConceptScore W1985364077C2778332380 @default.
• W1985364077 hasConceptScore W1985364077C2779349466 @default.
• W1985364077 hasConceptScore W1985364077C35271833 @default.
• W1985364077 hasConceptScore W1985364077C515207424 @default.
• W1985364077 hasConceptScore W1985364077C550995028 @default.
• W1985364077 hasConceptScore W1985364077C552990157 @default.
• W1985364077 hasConceptScore W1985364077C55493867 @default.
• W1985364077 hasConceptScore W1985364077C75972863 @default.
• W1985364077 hasConceptScore W1985364077C86803240 @default.
• W1985364077 hasIssue "4" @default.
• W1985364077 hasLocation W19853640771 @default.
• W1985364077 hasLocation W19853640772 @default.
• W1985364077 hasLocation W19853640773 @default.
• W1985364077 hasLocation W19853640774 @default.
• W1985364077 hasOpenAccess W1985364077 @default.
• W1985364077 hasPrimaryLocation W19853640771 @default.
• W1985364077 hasRelatedWork W1493509066 @default.
• W1985364077 hasRelatedWork W1984751161 @default.
• W1985364077 hasRelatedWork W1985364077 @default.
• W1985364077 hasRelatedWork W2028925368 @default.
• W1985364077 hasRelatedWork W2038775206 @default.
• W1985364077 hasRelatedWork W2054338789 @default.
• W1985364077 hasRelatedWork W2072261180 @default.
• W1985364077 hasRelatedWork W2086436616 @default.
• W1985364077 hasRelatedWork W2097955065 @default.
• W1985364077 hasRelatedWork W2111410460 @default.
• W1985364077 hasVolume "34" @default.

• next