FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985366863> ?p ?o ?g. }

• W1985366863 endingPage "398" @default.
• W1985366863 startingPage "385" @default.
• W1985366863 abstract "β3-adrenoceptors mediate some of the effects of catecholamines on tissues such as blood vessels or the urinary bladder and are putative targets for the treatment of diseases such as the overactive bladder syndrome. Progress in the understanding of the presence, function, and regulation of β3-adrenoceptors has been hampered by a lack of highly specific tools. “Classical” β3-adrenoceptor agonists such as BRL 37,344 [(R*, R*)-(±)-4[2-[(3-chlorophenyl)-2-hydroxyethyl) amino] propyl] phenoxyacetic acid] and CGP 12,177 [(±)-4-(3-t-butylamino-2-hydroxypropoxy)benzimidazol-2-one] are only partial agonists in many settings, have limited selectivity over other β-adrenoceptor subtypes, and may additionally act on receptors other than β-adrenoceptors. More efficacious and more selective agonists have been reported and, in some cases, are in clinical development but are not widely available for experimental studies. The widely used antagonist SR 59,230 [3-(2-ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanoloxalate] is not selective for β3-adrenoceptors, at least in humans, and may actually be a partial agonist. Radioligands, which are suitable either for the selective labeling of β3-adrenoceptors or for the nonselective labeling of all β-adrenoceptor subtypes, are also missing. β3- and β1/β2 double knockout mice have been reported, but their usefulness for extrapolations in humans is questionable based upon major differences between humans and rodents with regard to the ligand recognition and expression profiles of β3-adrenoceptors. While the common availability of more selective agonists and antagonists at the β3-adrenoceptor is urgently awaited, the limitations of the currently available tools need to be considered in studies of β3-adrenoceptor for the time being." @default.
• W1985366863 created "2016-06-24" @default.
• W1985366863 creator A5040869371 @default.
• W1985366863 creator A5056725548 @default.
• W1985366863 date "2007-01-09" @default.
• W1985366863 modified "2023-09-26" @default.
• W1985366863 title "Tools to study β3-adrenoceptors" @default.
• W1985366863 cites W109691321 @default.
• W1985366863 cites W1495418160 @default.
• W1985366863 cites W1498077467 @default.
• W1985366863 cites W1515847027 @default.
• W1985366863 cites W1520083061 @default.
• W1985366863 cites W1544739469 @default.
• W1985366863 cites W1548131418 @default.
• W1985366863 cites W1565178587 @default.
• W1985366863 cites W1574139946 @default.
• W1985366863 cites W1756573843 @default.
• W1985366863 cites W1795391938 @default.
• W1985366863 cites W1872730845 @default.
• W1985366863 cites W1891677971 @default.
• W1985366863 cites W1932873287 @default.
• W1985366863 cites W1946645080 @default.
• W1985366863 cites W1955035296 @default.
• W1985366863 cites W1963847575 @default.
• W1985366863 cites W1967359474 @default.
• W1985366863 cites W1971024460 @default.
• W1985366863 cites W1976627087 @default.
• W1985366863 cites W1977483894 @default.
• W1985366863 cites W1979818306 @default.
• W1985366863 cites W1980809057 @default.
• W1985366863 cites W1981470851 @default.
• W1985366863 cites W1982550159 @default.
• W1985366863 cites W1984141840 @default.
• W1985366863 cites W1984916194 @default.
• W1985366863 cites W1985689558 @default.
• W1985366863 cites W1985843619 @default.
• W1985366863 cites W1986794284 @default.
• W1985366863 cites W1989874074 @default.
• W1985366863 cites W1992879600 @default.
• W1985366863 cites W1996972993 @default.
• W1985366863 cites W1997481591 @default.
• W1985366863 cites W1997641444 @default.
• W1985366863 cites W1998435507 @default.
• W1985366863 cites W1999115737 @default.
• W1985366863 cites W1999506482 @default.
• W1985366863 cites W1999515762 @default.
• W1985366863 cites W2000421464 @default.
• W1985366863 cites W2000875883 @default.
• W1985366863 cites W2002896923 @default.
• W1985366863 cites W2003234447 @default.
• W1985366863 cites W2005575455 @default.
• W1985366863 cites W2007027676 @default.
• W1985366863 cites W2008736094 @default.
• W1985366863 cites W2009408345 @default.
• W1985366863 cites W2010572990 @default.
• W1985366863 cites W2012679882 @default.
• W1985366863 cites W2012808632 @default.
• W1985366863 cites W2015024290 @default.
• W1985366863 cites W2015936758 @default.
• W1985366863 cites W2017238946 @default.
• W1985366863 cites W2018430156 @default.
• W1985366863 cites W2019540567 @default.
• W1985366863 cites W2020113029 @default.
• W1985366863 cites W2020181071 @default.
• W1985366863 cites W2022169135 @default.
• W1985366863 cites W2022360041 @default.
• W1985366863 cites W2022923290 @default.
• W1985366863 cites W2023740260 @default.
• W1985366863 cites W2024436287 @default.
• W1985366863 cites W2025335579 @default.
• W1985366863 cites W2025370022 @default.
• W1985366863 cites W2028671417 @default.
• W1985366863 cites W2029265601 @default.
• W1985366863 cites W2030485468 @default.
• W1985366863 cites W2033189661 @default.
• W1985366863 cites W2033285271 @default.
• W1985366863 cites W2035221565 @default.
• W1985366863 cites W2035645910 @default.
• W1985366863 cites W2036134939 @default.
• W1985366863 cites W2037631372 @default.
• W1985366863 cites W2038667105 @default.
• W1985366863 cites W2038927385 @default.
• W1985366863 cites W2043827443 @default.
• W1985366863 cites W2044828679 @default.
• W1985366863 cites W2052941546 @default.
• W1985366863 cites W2052960454 @default.
• W1985366863 cites W2056916852 @default.
• W1985366863 cites W2057538250 @default.
• W1985366863 cites W2063082171 @default.
• W1985366863 cites W2067015973 @default.
• W1985366863 cites W2067399095 @default.
• W1985366863 cites W2068111510 @default.
• W1985366863 cites W2068868815 @default.
• W1985366863 cites W2070432389 @default.
• W1985366863 cites W2072515543 @default.
• W1985366863 cites W2072862004 @default.
• W1985366863 cites W2080039276 @default.
• W1985366863 cites W2082521167 @default.

• next