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- W1985366929 abstract "A series of substituted coumarins1-10 was designed and synthesized as a novel class of 4TCNA analogues. Compound 2a showed excellent antiproliferative activity with mean GI50 values at a micromolar level in a diverse set of human cancer cells (GI50 = 2-30 μM) and induced a high apoptosis level in MCF-7 breast cancer cell line. The molecular signature of hsp90 inhibition was assessed by depletion of the Erα hsp90 client protein." @default.
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- W1985366929 date "2014-08-01" @default.
- W1985366929 modified "2023-10-15" @default.
- W1985366929 title "Synthesis and antiproliferative activity of novobiocin analogues as potential hsp90 inhibitors" @default.
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- W1985366929 doi "https://doi.org/10.1016/j.ejmech.2014.06.067" @default.
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